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Schema
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Reaction
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Entries
ALK autophosphorylation
Show undefined attributes
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authored
[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
catalystActivity
[CatalystActivity:9700102] protein tyrosine kinase activity of ligand-bound ALK dimer [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
dbId
201521
displayName
ALK autophosphorylation
edited
[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-9700648] Active ALK binds SRC - Homo sapiens
[BlackBoxEvent:R-HSA-9701524] STAT3 is phosphorylated downstream of active ALK - Homo sapiens
[Reaction:R-HSA-9700142] Active ALK binds FRS2 - Homo sapiens
[Reaction:R-HSA-9701485] Active ALK binds JAK3 - Homo sapiens
[Reaction:R-HSA-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Homo sapiens
[Reaction:R-HSA-9700154] Active ALK binds SHC1 - Homo sapiens
[Reaction:R-HSA-9700156] Active ALK dimer binds IRS1 - Homo sapiens
[Reaction:R-HSA-9700149] Active ALK binds PLCG1 - Homo sapiens
[BlackBoxEvent:R-HSA-201515] Active ALK recruits PI3K - Homo sapiens
input
6 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[CandidateSet:R-HSA-9850908] ligand-bound ALK dimer [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9699630] Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway
[LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
[LiteratureReference:9699636] Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation
[LiteratureReference:9699668] Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
[LiteratureReference:9699789] Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity
[LiteratureReference:9699645] Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase
[LiteratureReference:9699717] Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
[LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
[LiteratureReference:9667905] Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
modified
[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name
ALK autophosphorylation
orthologousEvent
[Reaction:R-MMU-201521] ALK autophosphorylation - Mus musculus
[Reaction:R-RNO-201521] ALK autophosphorylation - Rattus norvegicus
[Reaction:R-CFA-201521] ALK autophosphorylation - Canis familiaris
[Reaction:R-BTA-201521] ALK autophosphorylation - Bos taurus
[Reaction:R-SSC-201521] ALK autophosphorylation - Sus scrofa
[Reaction:R-DRE-201521] ALK autophosphorylation - Danio rerio
[Reaction:R-GGA-201521] ALK autophosphorylation - Gallus gallus
output
[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane]
6 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-9842656] ALK binds ALKAL ligand - Homo sapiens
[Reaction:R-HSA-201519] ALK:PTN dimerization - Homo sapiens
[Reaction:R-HSA-9700137] ALK:MDK dimerization - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeRegulation:9700650] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'
releaseDate
2021-06-09
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-201521
summation
[Summation:9700129] ALK1 is phosphorylated on tyrosine residues in intracellular...
Referrals
(precedingEvent)
[Reaction:R-HSA-9700648] Active ALK binds SRC
[BlackBoxEvent:R-HSA-9701524] STAT3 is phosphorylated downstream of active ALK
[Reaction:R-HSA-9700142] Active ALK binds FRS2
[Reaction:R-HSA-9701485] Active ALK binds JAK3
[Reaction:R-HSA-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers
[Reaction:R-HSA-9700154] Active ALK binds SHC1
[Reaction:R-HSA-9700156] Active ALK dimer binds IRS1
[Reaction:R-HSA-9700149] Active ALK binds PLCG1
[BlackBoxEvent:R-HSA-201515] Active ALK recruits PI3K
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(normalReaction)
[Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK
[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions
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