Reactome | Active ALK binds SHC1

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Active ALK binds SHC1 Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9700152] Rothfels, Karen, 2020-09-14
dbId	9700154
displayName	Active ALK binds SHC1
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9700175] Active ALK phosphorylates SHC1 - Homo sapiens
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [DefinedSet:R-HSA-1169480] SHC1-2,SHC1-3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699627] ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth [LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation [LiteratureReference:9667905] Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase [LiteratureReference:9699630] Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway [LiteratureReference:201497] Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells [LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active ALK binds SHC1
orthologousEvent	[Reaction:R-GGA-9700154] Active ALK binds SHC1 - Gallus gallus [Reaction:R-SSC-9700154] Active ALK binds SHC1 - Sus scrofa [Reaction:R-BTA-9700154] Active ALK binds SHC1 - Bos taurus [Reaction:R-CFA-9700154] Active ALK binds SHC1 - Canis familiaris [Reaction:R-RNO-9700154] Active ALK binds SHC1 - Rattus norvegicus [Reaction:R-MMU-9700154] Active ALK binds SHC1 - Mus musculus
output	[Complex:R-HSA-9699970] Active ALK:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700154
summation	[Summation:9700153] SHC1 is recruited to the full-length ALK receptor after acti...
updateTrackers	[UpdateTracker:9853199] Update Tracker - [Reaction:9700154] Active ALK binds SHC1 - v87:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853199] Update Tracker - [Reaction:9700154] Active ALK binds SHC1 - v87:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9700175] Active ALK phosphorylates SHC1

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