Reactome | Active ALK recruits PI3K

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Active ALK recruits PI3K Show undefined attributes

authored	[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:201539] Jassal, B, 2007-08-21 12:50:53
dbId	201515
diseaseReaction	[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA - Homo sapiens
displayName	Active ALK recruits PI3K
edited	[InstanceEdit:201559] Jassal, B, 2007-08-21 12:55:28
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK - Homo sapiens
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [Complex:R-HSA-74693] PI3K [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway [LiteratureReference:201541] Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:201494] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin [LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active ALK recruits PI3K
orthologousEvent	[BlackBoxEvent:R-GGA-201515] Active ALK recruits PI3K - Gallus gallus [BlackBoxEvent:R-XTR-201515] Active ALK recruits PI3K - Xenopus tropicalis [BlackBoxEvent:R-DRE-201515] Active ALK recruits PI3K - Danio rerio [BlackBoxEvent:R-SSC-201515] Active ALK recruits PI3K - Sus scrofa [BlackBoxEvent:R-BTA-201515] Active ALK recruits PI3K - Bos taurus [BlackBoxEvent:R-CFA-201515] Active ALK recruits PI3K - Canis familiaris [BlackBoxEvent:R-RNO-201515] Active ALK recruits PI3K - Rattus norvegicus [BlackBoxEvent:R-MMU-201515] Active ALK recruits PI3K - Mus musculus
output	[Complex:R-HSA-9699995] Active ALK:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-201515
summation	[Summation:201538] Activated ALK in the form of NPM-ALK recruits PI3K. Binding ...
updateTrackers	[UpdateTracker:9853263] Update Tracker - [BlackBoxEvent:201515] Active ALK recruits PI3K - v87:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853263] Update Tracker - [BlackBoxEvent:201515] Active ALK recruits PI3K - v87:[addLiteratureReference, add_removeInput, modifyText]
(normalReaction)	[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK