Reactome | Signaling by ALK fusions and activated point mutants

Schema > Pathway > Entries

Signaling by ALK fusions and activated point mutants Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
created	[InstanceEdit:9725372] Rothfels, Karen, 2021-03-29
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9725370
disease	[Disease:1500689] cancer
displayName	Signaling by ALK fusions and activated point mutants
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9700206] Signaling by ALK in cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens [Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions - Homo sapiens [BlackBoxEvent:R-HSA-9724090] MYH9- and RNF213-ALK fusions are phosphorylated - Homo sapiens [Reaction:R-HSA-9700184] Ligand-independent dimerization of point mutants of ALK - Homo sapiens [Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK - Homo sapiens [Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens [Reaction:R-HSA-9712085] ALK mutants phosphorylate STAT3 - Homo sapiens [BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants - Homo sapiens [Reaction:R-HSA-9700190] ALK mutants bind SHC - Homo sapiens [Reaction:R-HSA-9700193] ALK mutants phosphorylate SHC1 - Homo sapiens [Reaction:R-HSA-9724099] ALK mutants:p-3Y SHC binds GRB2 - Homo sapiens [Reaction:R-HSA-9710914] ALK fusions bind GRB2 - Homo sapiens [Reaction:R-HSA-9712081] ALK fusions bind FRS - Homo sapiens [Reaction:R-HSA-9712087] ALK fusions phosphorylate FRS - Homo sapiens [Reaction:R-HSA-9712088] ALK fusion proteins bind IRS - Homo sapiens [Reaction:R-HSA-9712082] ALK fusions phosphorylate IRS1 - Homo sapiens [BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1 - Homo sapiens [Reaction:R-HSA-9712083] ALK mutants bind PI3KCA - Homo sapiens [Reaction:R-HSA-9712084] PI3K synthesizes PIP3 downstream of ALK mutants - Homo sapiens [Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 - Homo sapiens [Reaction:R-HSA-9712086] ALK fusions phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-9851114] NPM1-ALK-dependent TYK2 phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9851142] TYK2-dependent STAT1 and STAT3 phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9851112] NPM1-ALK- and TYK2-dependent MCL1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9851102] NPM1-ALK- and PI3K-dependent MDM2 phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9851096] NPM1-ALK- and JNK-dependent JUN phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9851098] NPM1-ALK- and JUN-dependent CDKN1A gene repression - Homo sapiens [BlackBoxEvent:R-HSA-9851078] NPM1-ALK-dependent MAPK8,9 phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9851079] p-T,Y MAPK8,9 translocate to the nucleus - Homo sapiens [Reaction:R-HSA-9851076] p-T,Y MAPK8,9 bind TP53 - Homo sapiens [BlackBoxEvent:R-HSA-9851077] JNK-dependent inhibition of TP53 ubiquitination - Homo sapiens [Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9718441] The role of the ALK receptor in cancer biology [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
maxDepth	3
modified	[InstanceEdit:9853043] Rothfels, Karen, 2023-11-09
name	Signaling by ALK fusions and activated point mutants
normalPathway	[Pathway:R-HSA-201556] Signaling by ALK
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9725370
summation	[Summation:9725537] ALK is activated in a range of cancers as a result of amplif...
updateTrackers	[UpdateTracker:9853241] Update Tracker - [Pathway:9725370] Signaling by ALK fusions and activated point mutants - v87:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775398] Update Tracker - [Pathway:9725370] Signaling by ALK fusions and activated point mutants - v79:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9700206] Signaling by ALK in cancer
(updatedInstance)	[UpdateTracker:9853241] Update Tracker - [Pathway:9725370] Signaling by ALK fusions and activated point mutants - v87:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775398] Update Tracker - [Pathway:9725370] Signaling by ALK fusions and activated point mutants - v79:[updateContainedRLE]

Cite Us!