Reactome | ASP-3026-resistant ALK mutants

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ASP-3026-resistant ALK mutants Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9717266] Rothfels, Karen, 2021-03-08
dbId	9717264
disease	[Disease:1500689] cancer
displayName	ASP-3026-resistant ALK mutants
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9700649] Drug resistance of ALK mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9700646] ASP-3026- resistant ALK mutants don't bind ASP-3026 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors [LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib [LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9717254] The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice [LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9717265] Escaping ALK inhibition: mechanisms of and strategies to overcome resistance
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ASP-3026-resistant ALK mutants
normalPathway	[Pathway:R-HSA-201556] Signaling by ALK
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9717264
summation	[Summation:9717248] ASP3026 is a second generation tyrosine kinase inhibitor wit...

Referrals

(hasEvent)

[Pathway:R-HSA-9700649] Drug resistance of ALK mutants