Reactome | Active ALK dimer binds IRS1

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Active ALK dimer binds IRS1 Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9700157] Rothfels, Karen, 2020-09-14
dbId	9700156
displayName	Active ALK dimer binds IRS1
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9700168] Active ALK phosphorylates IRS1 - Homo sapiens
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74769] IRS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9699627] ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth [LiteratureReference:9667905] Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase [LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells [LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active ALK dimer binds IRS1
orthologousEvent	[Reaction:R-GGA-9700156] Active ALK dimer binds IRS1 - Gallus gallus [Reaction:R-XTR-9700156] Active ALK dimer binds IRS1 - Xenopus tropicalis [Reaction:R-DRE-9700156] Active ALK dimer binds IRS1 - Danio rerio [Reaction:R-SSC-9700156] Active ALK dimer binds IRS1 - Sus scrofa [Reaction:R-BTA-9700156] Active ALK dimer binds IRS1 - Bos taurus [Reaction:R-CFA-9700156] Active ALK dimer binds IRS1 - Canis familiaris [Reaction:R-RNO-9700156] Active ALK dimer binds IRS1 - Rattus norvegicus [Reaction:R-MMU-9700156] Active ALK dimer binds IRS1 - Mus musculus
output	[Complex:R-HSA-9699993] Active ALK:IRS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700156
summation	[Summation:9700158] Phosphorylated tyrosine 1096 is the docking site for IRS1 on...
updateTrackers	[UpdateTracker:9853278] Update Tracker - [Reaction:9700156] Active ALK dimer binds IRS1 - v87:[addLiteratureReference, add_removeInput, modifyText]

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(updatedInstance)	[UpdateTracker:9853278] Update Tracker - [Reaction:9700156] Active ALK dimer binds IRS1 - v87:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9700168] Active ALK phosphorylates IRS1