Reactome | Signaling by ALK

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Signaling by ALK Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911636
displayName	Signaling by ALK
eventOf	[Pathway:R-DME-9006934] Signaling by Receptor Tyrosine Kinases - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-201510] PI3K synthesizes PIP3 downstream of ALK - Drosophila melanogaster [Reaction:R-DME-9701525] p-Y705,S727-STAT3 dimerizes - Drosophila melanogaster [BlackBoxEvent:R-DME-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Drosophila melanogaster [Pathway:R-DME-9701898] STAT3 nuclear events downstream of ALK signaling - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by ALK
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-201556
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9006934] Signaling by Receptor Tyrosine Kinases
(inferredTo)	[Pathway:R-HSA-201556] Signaling by ALK

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