Reactome | ALK binds ALKAL ligand

Schema > Reaction > Entries

ALK binds ALKAL ligand Show undefined attributes

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId	9842656
diseaseReaction	[Reaction:R-HSA-9700184] Ligand-independent dimerization of point mutants of ALK - Homo sapiens [Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens
displayName	ALK binds ALKAL ligand
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens [Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-201502] ALK [plasma membrane] [CandidateSet:R-HSA-9842597] ALKAL2:(ALKAL1) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome [LiteratureReference:9842539] FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase [LiteratureReference:9842433] Augmentor ? and ? (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions [LiteratureReference:9842490] Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-?) [LiteratureReference:9842445] Mechanism for the activation of the anaplastic lymphoma kinase receptor [LiteratureReference:9842419] Structural basis of cytokine-mediated activation of ALK family receptors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ALK binds ALKAL ligand
orthologousEvent	[Reaction:R-GGA-9842656] ALK binds ALKAL ligand - Gallus gallus [Reaction:R-XTR-9842656] ALK binds ALKAL ligand - Xenopus tropicalis [Reaction:R-DRE-9842656] ALK binds ALKAL ligand - Danio rerio [Reaction:R-SSC-9842656] ALK binds ALKAL ligand - Sus scrofa [Reaction:R-BTA-9842656] ALK binds ALKAL ligand - Bos taurus [Reaction:R-CFA-9842656] ALK binds ALKAL ligand - Canis familiaris [Reaction:R-RNO-9842656] ALK binds ALKAL ligand - Rattus norvegicus [Reaction:R-MMU-9842656] ALK binds ALKAL ligand - Mus musculus
output	[Complex:R-HSA-9842608] ALK dimer:ALKAL2:(ALKAL1) [plasma membrane]
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9842656
summation	[Summation:9842664] Signaling through the ALK receptor is activated by the bindi...

Referrals

(normalReaction)	[Reaction:R-HSA-9700184] Ligand-independent dimerization of point mutants of ALK [Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs [Reaction:R-HSA-201521] ALK autophosphorylation

Cite Us!