Reactome | Active ALK binds SRC

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Active ALK binds SRC Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9700663] Rothfels, Karen, 2020-09-16
dbId	9700648
displayName	Active ALK binds SRC
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9700647] Active ALK phosphorylates SRC - Homo sapiens
inferredFrom	[Reaction:R-NUL-9700661] Active ALK binds Src - Homo sapiens
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-354153] SRC-1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9700399] Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
maxDepth	1
modified	[InstanceEdit:9853043] Rothfels, Karen, 2023-11-09
name	Active ALK binds SRC
output	[Complex:R-HSA-9700422] Active ALK:SRC [plasma membrane]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700648
summation	[Summation:9700644] Based on studies with the oncogenic fusion protein NPM-ALK, ...
updateTrackers	[UpdateTracker:9853243] Update Tracker - [Reaction:9700648] Active ALK binds SRC - v87:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9853243] Update Tracker - [Reaction:9700648] Active ALK binds SRC - v87:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9700647] Active ALK phosphorylates SRC
(inferredTo)	[Reaction:R-NUL-9700661] Active ALK binds Src

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