Reactome | STAT3 nuclear events downstream of ALK signaling

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STAT3 nuclear events downstream of ALK signaling Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701899] Rothfels, Karen, 2020-09-28
dbId	9701898
displayName	STAT3 nuclear events downstream of ALK signaling
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens [Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers - Homo sapiens [Reaction:R-HSA-9701549] AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9701548] PRDM1 gene expression downstream of ALK signaling - Homo sapiens [Reaction:R-HSA-9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter - Homo sapiens [Reaction:R-HSA-9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene - Homo sapiens [BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling - Homo sapiens [Reaction:R-HSA-9701534] p-Y705, S727 STAT3 dimer binds HIF1A gene - Homo sapiens [BlackBoxEvent:R-HSA-9701569] ALK- and STAT3-dependent HIF1A gene expression - Homo sapiens [Reaction:R-HSA-9701537] p-Y705, S727 STAT3 dimer binds CD274 gene - Homo sapiens [BlackBoxEvent:R-HSA-9701562] CD274 gene expression downstream of ALK signaling - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701290] Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target [LiteratureReference:9701396] Revisiting STAT3 signalling in cancer: new and unexpected biological functions [LiteratureReference:9701333] STAT3: a multifaceted oncoprotein
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	STAT3 nuclear events downstream of ALK signaling
orthologousEvent	[Pathway:R-DDI-9701898] STAT3 nuclear events downstream of ALK signaling - Dictyostelium discoideum [Pathway:R-CEL-9701898] STAT3 nuclear events downstream of ALK signaling - Caenorhabditis elegans [Pathway:R-DME-9701898] STAT3 nuclear events downstream of ALK signaling - Drosophila melanogaster [Pathway:R-GGA-9701898] STAT3 nuclear events downstream of ALK signaling - Gallus gallus [Pathway:R-XTR-9701898] STAT3 nuclear events downstream of ALK signaling - Xenopus tropicalis [Pathway:R-SSC-9701898] STAT3 nuclear events downstream of ALK signaling - Sus scrofa [Pathway:R-BTA-9701898] STAT3 nuclear events downstream of ALK signaling - Bos taurus [Pathway:R-CFA-9701898] STAT3 nuclear events downstream of ALK signaling - Canis familiaris [Pathway:R-RNO-9701898] STAT3 nuclear events downstream of ALK signaling - Rattus norvegicus [Pathway:R-MMU-9701898] STAT3 nuclear events downstream of ALK signaling - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9701898
summation	[Summation:9701896] Activation of the STAT3 pathway downstream of ALK signaling ...
updateTrackers	[UpdateTracker:9853216] Update Tracker - [Pathway:9701898] STAT3 nuclear events downstream of ALK signaling - v87:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9853216] Update Tracker - [Pathway:9701898] STAT3 nuclear events downstream of ALK signaling - v87:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK

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