Reactome | Active ALK binds FRS2

Schema > Reaction > Entries

Active ALK binds FRS2 Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9700143] Rothfels, Karen, 2020-09-14
dbId	9700142
displayName	Active ALK binds FRS2
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent	[Reaction:R-HSA-9700164] Active ALK phosphorylates FRS2 - Homo sapiens
inferredFrom	[Reaction:R-NUL-9700145] Active ALK binds Frs2 - Rattus norvegicus
input	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-190244] FRS2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation [LiteratureReference:9699705] Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation
maxDepth	1
modified	[InstanceEdit:9853040] Rothfels, Karen, 2023-11-09
name	Active ALK binds FRS2
output	[Complex:R-HSA-9700006] Active ALK:FRS2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700142
summation	[Summation:9700144] The adaptor protein FRS2 binds activated ALK as assessed wit...
updateTrackers	[UpdateTracker:9853297] Update Tracker - [Reaction:9700142] Active ALK binds FRS2 - v87:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853297] Update Tracker - [Reaction:9700142] Active ALK binds FRS2 - v87:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)	[Reaction:R-HSA-9700164] Active ALK phosphorylates FRS2
(inferredTo)	[Reaction:R-NUL-9700145] Active ALK binds Frs2

Cite Us!