Reactome | NVP-TAE684-resistant ALK mutants

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NVP-TAE684-resistant ALK mutants Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9717302] Rothfels, Karen, 2021-03-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9717301
disease	[Disease:1500689] cancer
displayName	NVP-TAE684-resistant ALK mutants
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9700649] Drug resistance of ALK mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors [LiteratureReference:9701779] A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NVP-TAE684-resistant ALK mutants
normalPathway	[Pathway:R-HSA-201556] Signaling by ALK
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9717301
summation	[Summation:9717300] NVP TAE684 is a second generation tyrosine kinase inhibitor ...

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(hasEvent)

[Pathway:R-HSA-9700649] Drug resistance of ALK mutants

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