Reactome | ALK mutants bind TKIs

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ALK mutants bind TKIs Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
created	[InstanceEdit:9700663] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700645
disease	[Disease:1500689] cancer
displayName	ALK mutants bind TKIs
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9700206] Signaling by ALK in cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9700131] ALK mutants bind type I TKIs - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9717265] Escaping ALK inhibition: mechanisms of and strategies to overcome resistance [LiteratureReference:9717312] Targeting ALK: Precision Medicine Takes on Drug Resistance [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK mutants bind TKIs
normalPathway	[Pathway:R-HSA-201556] Signaling by ALK
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9700645
summation	[Summation:9700657] Aberrant signaling by activated forms of ALK can be inhibite...
updateTrackers	[UpdateTracker:9853212] Update Tracker - [Pathway:9700645] ALK mutants bind TKIs - v87:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9853212] Update Tracker - [Pathway:9700645] ALK mutants bind TKIs - v87:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9700206] Signaling by ALK in cancer

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