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Schema
>
LiteratureReference
>
Entries
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
Show undefined attributes
author
[Person:1980028] Weiss, J
[Person:1980009] Sos, ML
[Person:1979998] Seidel, D
[Person:1979983] Peifer, M
[Person:1980034] Zander, T
[Person:1979957] Heuckmann, JM
[Person:1980022] Ullrich, RT
[Person:1979977] Menon, R
[Person:1979975] Maier, S
[Person:1980007] Soltermann, A
[Person:1979980] Moch, H
[Person:1980023] Wagener, P
[Person:1979948] Fischer, F
[Person:1979962] Heynck, S
[Person:1979965] Koker, M
[Person:1979996] Schöttle, J
[Person:1979967] Leenders, F
[Person:1979949] Gabler, F
[Person:1979939] Dabow, I
[Person:1979989] Querings, S
[Person:1979959] Heukamp, LC
[Person:1979919] Balke-Want, H
[Person:1979916] Ansén, S
[Person:1979991] Rauh, D
[Person:1979918] Baessmann, I
[Person:1979914] Altmüller, J
[Person:1980026] Wainer, Z
[Person:1979938] Conron, M
[Person:1980032] Wright, G
[Person:1979993] Russell, P
[Person:1980005] Solomon, B
[Person:1979927] Brambilla, E
[Person:1979925] Brambilla, C
[Person:1979971] Lorimier, P
[Person:1980004] Sollberg, S
[Person:1979929] Brustugun, OT
[Person:1979943] Engel-Riedel, W
[Person:1979974] Ludwig, C
[Person:1979988] Petersen, I
[Person:1980014] Sänger, J
[Person:1979936] Clement, J
[Person:1979951] Groen, H
[Person:1980019] Timens, W
[Person:1980000] Sietsma, H
[Person:1980018] Thunnissen, E
[Person:1980002] Smit, E
[Person:1979955] Heideman, D
[Person:1979934] Cappuzzo, F
[Person:1979970] Ligorio, C
[Person:1979941] Damiani, S
[Person:1979954] Hallek, M
[Person:1979923] Beroukhim, R
[Person:1181043] Pao, W
[Person:1979963] Klebl, B
[Person:1979922] Baumann, M
[Person:1979932] Buettner, R
[Person:1979946] Ernestus, K
[Person:1980012] Stoelben, E
[Person:1980030] Wolf, J
[Person:1979982] Nürnberg, P
[Person:1979986] Perner, S
[Person:1980015] Thomas, RK
created
[InstanceEdit:1982029] Rothfels, K, 2011-11-09
dbId
1982028
displayName
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
journal
Sci Transl Med
pages
62ra93
pubMedIdentifier
21160078
schemaClass
LiteratureReference
title
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
url
http://www.ncbi.nlm.nih.gov/pubmed/21160078
volume
2
year
2010
Referrals
(author)
[Person:1980000] Sietsma, H
[Person:1980002] Smit, E
[Person:1980005] Solomon, B
[Person:1980004] Sollberg, S
[Person:1980007] Soltermann, A
[Person:1980009] Sos, ML
[Person:1980012] Stoelben, E
[Person:1980015] Thomas, RK
[Person:1980014] Sänger, J
[Person:1980019] Timens, W
[Person:1980018] Thunnissen, E
[Person:1980023] Wagener, P
[Person:1979934] Cappuzzo, F
[Person:1979932] Buettner, R
[Person:1979929] Brustugun, OT
[Person:1979927] Brambilla, E
[Person:1979925] Brambilla, C
[Person:1979922] Baumann, M
[Person:1979923] Beroukhim, R
[Person:1979918] Baessmann, I
[Person:1979919] Balke-Want, H
[Person:1979916] Ansén, S
[Person:1979914] Altmüller, J
[Person:1980034] Zander, T
[Person:1980032] Wright, G
[Person:1979967] Leenders, F
[Person:1979965] Koker, M
[Person:1979962] Heynck, S
[Person:1979963] Klebl, B
[Person:1979959] Heukamp, LC
[Person:1979957] Heuckmann, JM
[Person:1979954] Hallek, M
[Person:1979955] Heideman, D
[Person:1979951] Groen, H
[Person:1979948] Fischer, F
[Person:1979949] Gabler, F
[Person:1979946] Ernestus, K
[Person:1979943] Engel-Riedel, W
[Person:1979941] Damiani, S
[Person:1979938] Conron, M
[Person:1979939] Dabow, I
[Person:1979936] Clement, J
[Person:1979998] Seidel, D
[Person:1979996] Schöttle, J
[Person:1979993] Russell, P
[Person:1979991] Rauh, D
[Person:1979988] Petersen, I
[Person:1979989] Querings, S
[Person:1979986] Perner, S
[Person:1979982] Nürnberg, P
[Person:1979983] Peifer, M
[Person:1979980] Moch, H
[Person:1979977] Menon, R
[Person:1979974] Ludwig, C
[Person:1979975] Maier, S
[Person:1979970] Ligorio, C
[Person:1979971] Lorimier, P
[Person:1980030] Wolf, J
[Person:1181043] Pao, W
[Person:1980028] Weiss, J
[Person:1980026] Wainer, Z
[Person:1980022] Ullrich, RT
(literatureReference)
[Pathway:R-HSA-1226099] Signaling by FGFR in disease
[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Complex:R-HSA-5655267] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655308] Activated FGFR4 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655351] Activated FGFR4 mutants bind FRS2
[Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655339] Activated FGFR2 mutants bind FRS2
[Complex:R-HSA-5655337] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655277] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Reaction:R-HSA-5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2
[Reaction:R-HSA-5655315] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Complex:R-HSA-5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Complex:R-HSA-5655238] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Complex:R-HSA-5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants
[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1
[Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b
[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane]
[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c
[Reaction:R-HSA-5654544] Ligand-independent dimerization of overexpressed FGFR1c
[Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655269] Activated FGFR1 mutants bind FRS2
[DefinedSet:R-HSA-1982041] Activated overexpressed FGFR1 homodimers [plasma membrane]
[Complex:R-HSA-1982036] Activated overexpressed FGFR1c homodimer [plasma membrane]
[Complex:R-HSA-1982038] Activated overexpressed FGFR1b homodimer [plasma membrane]
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