Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
LiteratureReference
>
Entries
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
Show undefined attributes
author
[Person:1980028] Weiss, J
[Person:1980009] Sos, ML
[Person:1979998] Seidel, D
[Person:1979983] Peifer, M
[Person:1980034] Zander, T
[Person:1979957] Heuckmann, JM
[Person:1980022] Ullrich, RT
[Person:1979977] Menon, R
[Person:1979975] Maier, S
[Person:1980007] Soltermann, A
[Person:1979980] Moch, H
[Person:1980023] Wagener, P
[Person:1979948] Fischer, F
[Person:1979962] Heynck, S
[Person:1979965] Koker, M
[Person:1979996] Schöttle, J
[Person:1979967] Leenders, F
[Person:1979949] Gabler, F
[Person:1979939] Dabow, I
[Person:1979989] Querings, S
[Person:1979959] Heukamp, LC
[Person:1979919] Balke-Want, H
[Person:1979916] Ansén, S
[Person:1979991] Rauh, D
[Person:1979918] Baessmann, I
[Person:1979914] Altmüller, J
[Person:1980026] Wainer, Z
[Person:1979938] Conron, M
[Person:1980032] Wright, G
[Person:1979993] Russell, P
[Person:1980005] Solomon, B
[Person:1979927] Brambilla, E
[Person:1979925] Brambilla, C
[Person:1979971] Lorimier, P
[Person:1980004] Sollberg, S
[Person:1979929] Brustugun, OT
[Person:1979943] Engel-Riedel, W
[Person:1979974] Ludwig, C
[Person:1979988] Petersen, I
[Person:1980014] Sänger, J
[Person:1979936] Clement, J
[Person:1979951] Groen, H
[Person:1980019] Timens, W
[Person:1980000] Sietsma, H
[Person:1980018] Thunnissen, E
[Person:1980002] Smit, E
[Person:1979955] Heideman, D
[Person:1979934] Cappuzzo, F
[Person:1979970] Ligorio, C
[Person:1979941] Damiani, S
[Person:1979954] Hallek, M
[Person:1979923] Beroukhim, R
[Person:1181043] Pao, W
[Person:1979963] Klebl, B
[Person:1979922] Baumann, M
[Person:1979932] Buettner, R
[Person:1979946] Ernestus, K
[Person:1980012] Stoelben, E
[Person:1980030] Wolf, J
[Person:1979982] Nürnberg, P
[Person:1979986] Perner, S
[Person:1980015] Thomas, RK
created
[InstanceEdit:1982029] Rothfels, K, 2011-11-09
dbId
1982028
displayName
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
journal
Sci Transl Med
pages
62ra93
pubMedIdentifier
21160078
schemaClass
LiteratureReference
title
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
url
http://www.ncbi.nlm.nih.gov/pubmed/21160078
volume
2
year
2010
Referrals
(author)
[Person:1980000] Sietsma, H
[Person:1980002] Smit, E
[Person:1980005] Solomon, B
[Person:1980004] Sollberg, S
[Person:1980007] Soltermann, A
[Person:1980009] Sos, ML
[Person:1980012] Stoelben, E
[Person:1980015] Thomas, RK
[Person:1980014] Sänger, J
[Person:1980019] Timens, W
[Person:1980018] Thunnissen, E
[Person:1980023] Wagener, P
[Person:1979934] Cappuzzo, F
[Person:1979932] Buettner, R
[Person:1979929] Brustugun, OT
[Person:1979927] Brambilla, E
[Person:1979925] Brambilla, C
[Person:1979922] Baumann, M
[Person:1979923] Beroukhim, R
[Person:1979918] Baessmann, I
[Person:1979919] Balke-Want, H
[Person:1979916] Ansén, S
[Person:1979914] Altmüller, J
[Person:1980034] Zander, T
[Person:1980032] Wright, G
[Person:1979967] Leenders, F
[Person:1979965] Koker, M
[Person:1979962] Heynck, S
[Person:1979963] Klebl, B
[Person:1979959] Heukamp, LC
[Person:1979957] Heuckmann, JM
[Person:1979954] Hallek, M
[Person:1979955] Heideman, D
[Person:1979951] Groen, H
[Person:1979948] Fischer, F
[Person:1979949] Gabler, F
[Person:1979946] Ernestus, K
[Person:1979943] Engel-Riedel, W
[Person:1979941] Damiani, S
[Person:1979938] Conron, M
[Person:1979939] Dabow, I
[Person:1979936] Clement, J
[Person:1979998] Seidel, D
[Person:1979996] Schöttle, J
[Person:1979993] Russell, P
[Person:1979991] Rauh, D
[Person:1979988] Petersen, I
[Person:1979989] Querings, S
[Person:1979986] Perner, S
[Person:1979982] Nürnberg, P
[Person:1979983] Peifer, M
[Person:1979980] Moch, H
[Person:1979977] Menon, R
[Person:1979974] Ludwig, C
[Person:1979975] Maier, S
[Person:1979970] Ligorio, C
[Person:1979971] Lorimier, P
[Person:1980030] Wolf, J
[Person:1181043] Pao, W
[Person:1980028] Weiss, J
[Person:1980026] Wainer, Z
[Person:1980022] Ullrich, RT
(literatureReference)
[Pathway:R-HSA-1226099] Signaling by FGFR in disease
[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Complex:R-HSA-5655267] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655308] Activated FGFR4 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655351] Activated FGFR4 mutants bind FRS2
[Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655339] Activated FGFR2 mutants bind FRS2
[Complex:R-HSA-5655337] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655277] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Reaction:R-HSA-5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2
[Reaction:R-HSA-5655315] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Complex:R-HSA-5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Complex:R-HSA-5655238] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Complex:R-HSA-5655217] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants
[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1
[Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b
[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane]
[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c
[Reaction:R-HSA-5654544] Ligand-independent dimerization of overexpressed FGFR1c
[Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
[Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[Reaction:R-HSA-5655269] Activated FGFR1 mutants bind FRS2
[DefinedSet:R-HSA-1982041] Activated overexpressed FGFR1 homodimers [plasma membrane]
[Complex:R-HSA-1982036] Activated overexpressed FGFR1c homodimer [plasma membrane]
[Complex:R-HSA-1982038] Activated overexpressed FGFR1b homodimer [plasma membrane]
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text