Reactome | Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers

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Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2023463] Rothfels, K, 2011-12-07
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2023462
disease	[Disease:1500689] cancer
displayName	Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654548] gain_of_function of Overexpressed FGFR1 homodimers [plasma membrane]
eventOf	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants - Homo sapiens
input	[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane] 2 × [DefinedSet:R-ALL-2023441] Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer [LiteratureReference:2011997] FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
output	[Complex:R-HSA-2023442] Overexpressed FGFR1:TKIs [plasma membrane]
precedingEvent	[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2023462
summation	[Summation:2054058] Treatment of FGFR1-amplified lung and breast cancer cell lin...

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[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants

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