Reactome | Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1

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Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655248
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655325] gain_of_function of Activated FGFR4 mutants:p-FRS2 [plasma membrane]
eventOf	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
input	[Complex:R-HSA-5655308] Activated FGFR4 mutants:p-FRS2 [plasma membrane] [Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
normalReaction	[Reaction:R-HSA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
output	[Complex:R-HSA-5655344] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655248
summation	[Summation:1986644] FGFR1-amplified cells derived from lung cancer patients show...

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[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease

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