Reactome | Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:5655329] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655337
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
hasComponent	[Complex:R-HSA-5655330] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
name	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K
producedByEvent	[Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5655337

(diseaseEntity)	[EntityFunctionalStatus:5655283] gain_of_function of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(physicalEntity)	[CatalystActivity:5655329] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(output)	[Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

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