Reactome | Activated FGFR1 mutants:p-FRS2 [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens [Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
created	[InstanceEdit:5655219] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655216
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR1 mutants:p-FRS2 [plasma membrane]
hasComponent	[DefinedSet:R-HSA-5655215] Activated FGFR1 mutants [plasma membrane] [EntityWithAccessionedSequence:R-HSA-170959] p-6Y-FRS2 [plasma membrane]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
maxDepth	6
name	Activated FGFR1 mutants:p-FRS2
producedByEvent	[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5655216
updateTrackers	[UpdateTracker:9893444] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9897003] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v61:[updateContainedComponent] [UpdateTracker:9965165] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v94:[updateContainedComponent] [UpdateTracker:9898997] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v64:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9893444] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9897003] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v61:[updateContainedComponent] [UpdateTracker:9965165] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v94:[updateContainedComponent] [UpdateTracker:9898997] Update Tracker - [Complex:5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] - v64:[updateContainedComponent]
(input)	[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 [Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
(diseaseEntity)	[EntityFunctionalStatus:9632021] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane] [EntityFunctionalStatus:5655256] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
(hasComponent)	[Complex:R-HSA-5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
(output)	[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2

Activated FGFR1 mutants:p-FRS2 [plasma membrane] Show undefined attributes

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