Reactome | Signaling by FGFR1 amplification mutants

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Signaling by FGFR1 amplification mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:1839119] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	1839120
disease	[Disease:1500689] cancer
displayName	Signaling by FGFR1 amplification mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b - Homo sapiens [Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1 - Homo sapiens [Reaction:R-HSA-5654544] Ligand-independent dimerization of overexpressed FGFR1c - Homo sapiens [Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c - Homo sapiens [Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1986648] Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development [LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer [LiteratureReference:2012016] Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC) [LiteratureReference:2012006] High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications [LiteratureReference:2012008] High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer [LiteratureReference:2012003] Gene amplifications associated with the development of hormone-resistant prostate cancer [LiteratureReference:2012011] Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition [LiteratureReference:2012018] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas [LiteratureReference:2011992] Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer [LiteratureReference:2012004] Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines [LiteratureReference:2011999] Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells [LiteratureReference:2011997] FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas [LiteratureReference:2012000] Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by FGFR1 amplification mutants
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1839120
summation	[Summation:2012091] Amplification or activation of FGFR1 has been reported in l...
updateTrackers	[UpdateTracker:9785027] Update Tracker - [Pathway:1839120] Signaling by FGFR1 amplification mutants - v52:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9785027] Update Tracker - [Pathway:1839120] Signaling by FGFR1 amplification mutants - v52:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation

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