Reactome | Activated overexpressed FGFR1c homodimer [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1982037] Rothfels, K, 2011-11-09
crossReference	[DatabaseIdentifier:12020755] Mondo:0008903
dbId	1982036
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1981182] lung squamous cell carcinoma
displayName	Activated overexpressed FGFR1c homodimer [plasma membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-190434] p-8Y-FGFR1c [plasma membrane]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
maxDepth	2
memberOf	[DefinedSet:R-HSA-1982041] Activated overexpressed FGFR1 homodimers [plasma membrane] - Homo sapiens
name	Activated overexpressed FGFR1c homodimer
producedByEvent	[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1982036

(output)	[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c
(hasMember)	[DefinedSet:R-HSA-1982041] Activated overexpressed FGFR1 homodimers [plasma membrane]

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