Reactome | Activated FGFR2 mutants bind FRS2

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Activated FGFR2 mutants bind FRS2 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655339
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR2 mutants bind FRS2
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655334] gain_of_function of Activated FGFR2 mutants [plasma membrane]
eventOf	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
input	[DefinedSet:R-HSA-5654747] Activated FGFR2 mutants [plasma membrane] [EntityWithAccessionedSequence:R-HSA-170963] FRS2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR2 mutants bind FRS2
normalReaction	[Reaction:R-HSA-5654399] Activated FGFR2 binds FRS2
output	[Complex:R-HSA-5655257] Activated FGFR2 mutants:FRS2 [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655339
summation	[Summation:1982075] After activation, FGFR mutants are presumed to recruit FRS2 ...

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(hasEvent)

[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease