Reactome | Ligand-independent dimerization of overexpressed FGFR1b

Schema > Reaction > Entries

Ligand-independent dimerization of overexpressed FGFR1b Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1982063] Rothfels, K, 2011-11-09
dbId	1982065
disease	[Disease:1500689] cancer
displayName	Ligand-independent dimerization of overexpressed FGFR1b
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654529] gain_of_function of FGFR1b [plasma membrane]
eventOf	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1 - Homo sapiens [Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-189878] FGFR1b [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2054033] Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of overexpressed FGFR1b
output	[Complex:R-HSA-190228] FGFR1b homodimer [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1982065
summation	[Summation:1982064] FGFR1-amplified lung cancer and breast cancer cells show str...

Referrals

(hasEvent)	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants
(precedingEvent)	[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1 [Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers