Reactome | Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]

catalystActivities	[CatalystActivity:5655273] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655294
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
hasComponent	[Complex:R-HSA-5655271] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74787] PIK3CA [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
maxDepth	7
modified	[InstanceEdit:9753857] Rothfels, Karen, 2021-09-15
name	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K
producedByEvent	[Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5655294
updateTrackers	[UpdateTracker:9898032] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent] [UpdateTracker:9893680] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9902802] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v79:[modifyName, updateContainedComponent] [UpdateTracker:9965164] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v94:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9898032] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v63:[updateContainedComponent] [UpdateTracker:9893680] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v56:[updateContainedComponent] [UpdateTracker:9902802] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v79:[modifyName, updateContainedComponent] [UpdateTracker:9965164] Update Tracker - [Complex:5655294] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] - v94:[updateContainedComponent]
(diseaseEntity)	[EntityFunctionalStatus:5655286] gain_of_function of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(physicalEntity)	[CatalystActivity:5655273] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
(output)	[Reaction:R-HSA-5655285] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] Show undefined attributes

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