Reactome | Ligand-independent dimerization of overexpressed FGFR1c

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Ligand-independent dimerization of overexpressed FGFR1c Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654543] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5654544
disease	[Disease:1500689] cancer
displayName	Ligand-independent dimerization of overexpressed FGFR1c
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654542] gain_of_function of FGFR1c [plasma membrane]
eventOf	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-189897] FGFR1c [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2054033] Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of overexpressed FGFR1c
output	[Complex:R-HSA-190222] FGFR1c homodimer [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654544
summation	[Summation:1982064] FGFR1-amplified lung cancer and breast cancer cells show str...

Referrals

(precedingEvent)	[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c
(hasEvent)	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants

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