Leda Raptis

 ORCID
https://orcid.org/0000-0002-6517-4429
Affiliation
Department of Pathology and Molecular Medicine, Queen?s University
Authored Pathways (2/2)
Date Identifier Pathway Reference
2025-05-25 R-HSA-9958825 Activation of STAT3 by cadherin engagement BibTex
2025-05-25 R-HSA-9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) BibTex
Authored Reactions (5/5)
Date Identifier Reaction Reference
2025-05-25 R-MMU-9984065 26S proteasome degrades ubiquitinated Rac1, Cdc42 BibTex
2025-05-25 R-HSA-9958874 26S proteasome degrades ubiquitinated RAC1, CDC42 BibTex
2025-05-25 R-NUL-9968039 SRC downregulates Cdh11 BibTex
2025-05-25 R-HSA-9958891 SRC downregulates CDH11 BibTex
2025-05-25 R-HSA-9958873 Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination BibTex
Reviewed Pathways (2/2)
Date Identifier Pathway Reference
2025-11-21 R-HSA-9958825 Activation of STAT3 by cadherin engagement BibTex
2025-11-21 R-HSA-9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) BibTex
Reviewed Reactions (38/38)
Date Identifier Reaction Reference
2025-11-21 R-HSA-9958874 26S proteasome degrades ubiquitinated RAC1, CDC42 BibTex
2025-11-21 R-MMU-9984065 26S proteasome degrades ubiquitinated Rac1, Cdc42 BibTex
2025-11-21 R-HSA-9968598 CDH1,CDH11 promote stabilization of IL6ST protein BibTex
2025-11-21 R-MMU-9968619 Il6st protein stabilization by Cdh1,Cdh11 BibTex
2025-11-21 R-HSA-9958891 SRC downregulates CDH11 BibTex
2025-11-21 R-NUL-9968039 SRC downregulates Cdh11 BibTex
2025-11-21 R-HSA-9958889 SRC phosphorylates CDH1 BibTex
2025-11-21 R-HSA-9970163 SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42) BibTex
2025-11-21 R-HSA-9958892 SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs BibTex
2025-11-21 R-HSA-9958873 Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination BibTex
2025-11-21 R-HSA-9934410 CDH1 forms homotypic trans-dimers BibTex
2025-11-21 R-HSA-9934294 CDH1-associated CTNNA1 binds VCL BibTex
2025-11-21 R-HSA-9934486 CDH1-associated CTNNA1 binds F-actin BibTex
2025-11-21 R-HSA-9934411 CDH1 forms cis-clusters BibTex
2025-11-21 R-HSA-9935547 Lysosomal degradation of ubiquitinated CDH1 BibTex
2025-11-21 R-HSA-9935552 Ubiquitinated CDH1 translocates to lysosomes for degradation BibTex
2025-11-21 R-HSA-9934752 Ubiquitinated CDH1 is endocytosed BibTex
2025-11-21 R-HSA-9934753 CBLL1 ubiquitinates CDH1 BibTex
2025-11-21 R-HSA-9934755 CBLL1 binds p-Y-CDH1 BibTex
2025-11-21 R-HSA-9833674 CDH11 forms homotypic trans dimers BibTex
2025-11-21 R-HSA-2730599 Phosphorylated STAT3 Dimer Translocates to the Nucleus BibTex
2025-11-21 R-MMU-2730598 Phosphorylated Stat3 Dimer Translocates to the Nucleus BibTex
2025-11-21 R-HSA-2730595 Phosphorylated STAT3 Forms Dimers BibTex
2025-11-21 R-MMU-2730597 Phosphorylated Stat3 Forms Dimer BibTex
2025-11-21 R-HSA-9958877 p-Y705-STAT3 dissociates from IL6 receptor BibTex
2025-11-21 R-HSA-9958871 Tyrosine phosphorylation of STAT3 by IL6 receptor BibTex
2025-11-21 R-HSA-9958878 Tyrosine phosphorylated IL6ST binds STAT3 BibTex
2025-11-21 R-HSA-1112510 IL6ST is tyrosine phosphorylated BibTex
2025-11-21 R-HSA-1112514 JAK activation BibTex
2025-11-21 R-HSA-1067659 Assembly of hexameric IL-6 receptor BibTex
2025-11-21 R-HSA-1067688 IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) BibTex
2025-11-21 R-HSA-1067667 IL6 binds IL6R BibTex
2025-11-21 R-HSA-9958875 NF?B stimulates IL6 gene expression BibTex
2025-11-21 R-HSA-9958869 Activated NF?B complex binds IL6 gene promoter BibTex
2025-11-21 R-HSA-9958872 RAC1, CDC42 activate NF?B BibTex
2025-11-21 R-HSA-1067651 IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) BibTex
2025-11-21 R-HSA-1067646 JAK1,JAK2,(TYK2) bind IL6ST BibTex
2025-11-21 R-HSA-1067640 IL6 binds IL6R-2 BibTex
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