Phosphorylated STAT3 Forms Dimers

Stable Identifier
R-HSA-2730595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As inferred from mouse, both non-phosphorylated and phosphorylated STAT3 can form dimers and enter the nucleus. Phosphorylation of STAT3 appears to change the equilibrium between these states, causing accumulation of phosphorylated STAT3 in the nucleus. Phosphorylated STAT3 dimers also activate transcription more efficiently.

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