IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)

Stable Identifier
R-HSA-1067688
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL6:IL6R binds IL6ST:JAKs
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IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
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The complex of interleukin-6 (IL6) bound to the IL6 receptor alpha subunit (IL6R) binds the IL-6 receptor beta subunit IL6ST (gp130), which constitutively binds JAK kinases. Site II of IL6 interacts with the cytokine binding-homology region of IL6ST. Subsequently, site III of IL6 interacts with the IL6ST immunoglobulin-like activation domain.

Literature References
PubMed ID Title Journal Year
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y

Cell 1989
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Orthologous Events
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Bos taurus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Danio rerio)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Rattus norvegicus)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-11-26)
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