The complex of interleukin-6 (IL6) bound to the IL6 receptor alpha subunit (IL6R) binds the IL-6 receptor beta subunit IL6ST (gp130), which constitutively binds JAK kinases. Site II of IL6 interacts with the cytokine binding-homology region of IL6ST. Subsequently, site III of IL6 interacts with the IL6ST immunoglobulin-like activation domain.
Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y
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