SRC downregulates Cdh11

Stable Identifier
R-NUL-9968039
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SRC downregulates Cdh11
Ectopic expression of the constitutively active chicken SRC-Y527F mutant in the mouse fibroblast cell line Balb/c3T3, leads to downregulation of Cdh11. The mechanism has not been examined further (Adan et al. 2022).
Literature References
PubMed ID Title Journal Year
35411090 Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts

Adan, H, Guy, S, Arulanandam, R, Geletu, M, Daniel, J, Raptis, L

Cancer Gene Ther 2022
Participants
Input
This event is regulated
Positively by
Regulator
MyrG-p-Y416-SRC [plasma membrane] (Gallus gallus)
Orthologous Events
SRC downregulates CDH11 (Homo sapiens)
Authored
Adan, H  (2025-05-25)
Daniel, J  (2025-05-25)
Raptis, L  (2025-05-25)
Reviewed
Raptis, L  (2025-11-21)
Created
Orlic-Milacic, M  (2025-10-08)
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