IL6 binds IL6R

Stable Identifier
R-HSA-1067667
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Synonyms
Interleukin-6 binds to IL-6 receptor alpha subunit
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL6 binds IL6R
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Interleukin-6 (IL6) site I interacts with the Interleukin-6 receptor subunit α (IL6Rα), which is non-signaling but ligand-specific (Taga et al. 1989).
Literature References
PubMed ID Title Journal Year
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Taga, T, Hibi, M, Hirata, Y, Yamasaki, K, Yasukawa, K, Matsuda, T, Hirano, T, Kishimoto, T

Cell 1989
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
Orthologous Events
IL6 binds IL6R (Bos taurus)
IL6 binds IL6R (Canis familiaris)
IL6 binds IL6R (Danio rerio)
IL6 binds IL6R (Gallus gallus)
IL6 binds IL6R (Mus musculus)
IL6 binds IL6R (Rattus norvegicus)
IL6 binds IL6R (Sus scrofa)
IL6 binds IL6R (Xenopus tropicalis)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Raptis, L  (2025-11-21)
Created
Jupe, S  (2010-11-26)
Cite Us!