Reactome | CDH1-associated CTNNA1 binds F-actin

CDH1-associated CTNNA1 binds F-actin

Stable Identifier

R-HSA-9934486

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Activation of STAT3 by cadherin engagement (Homo sapiens)
        
        CDH1-associated CTNNA1 binds F-actin (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Function (Homo sapiens)
        
        CDH1-associated CTNNA1 binds F-actin (Homo sapiens)

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CTNNA1 (α-catenin) is responsible for the recruitment of F-actin polymers to the CDH1 complex (Watabe-Uchida et al. 1998: human colon carcinoma cell line; Wu et al. 2015: human epidermoid carcinoma cell line; Morales-Camilo et al. 2024: canine MDCK cell line; reviewed in Zhang et al. 2023). CTNNA1 can dimerize when clustered, which increases its binding affinity for F-actin (reviewed in Zhang et al. 2023).

Literature References

PubMed ID	Title	Journal	Year
9700171	alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells Watabe-Uchida, M, Uchida, N, Imamura, Y, Nagafuchi, A, Fujimoto, K, Uemura, T, Vermeulen, S, van Roy, F, Adamson, ED, Takeichi, M	J Cell Biol	1998
25600236	Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions Wu, Y, Kanchanawong, P, Zaidel-Bar, R	Dev Cell	2015