Phosphorylated Stat3 Dimer Translocates to the Nucleus

Stable Identifier
R-MMU-2730598
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylated Stat3 Dimer Translocates to the Nucleus

Stat3 dimers are imported into the nucleus by the importin alpha/beta pathway. Stat3 constitutively shuttles into and out of the nucleus. The unphosphorylated form is predominantly cytosolic. Phosphorylation of Stat3 shifts the distribution from the cytosol to the nucleus.

Literature References
PubMed ID Title Journal Year
14701810 Real time analysis of STAT3 nucleocytoplasmic shuttling

Pranada, AL, Metz, S, Herrmann, A, Heinrich, PC, Müller-Newen, G

J. Biol. Chem. 2004
15919823 STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3

Liu, L, McBride, KM, Reich, NC

Proc. Natl. Acad. Sci. U.S.A. 2005
21625522 Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-?1

Cimica, V, Chen, HC, Iyer, JK, Reich, NC

PLoS ONE 2011
21325026 The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3

Vogt, M, Domoszlai, T, Kleshchanok, D, Lehmann, S, Schmitt, A, Poli, V, Richtering, W, Müller-Newen, G

J. Cell. Sci. 2011
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