26S proteasome degrades ubiquitinated Rac1, Cdc42

Stable Identifier
R-MMU-9984065
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
26S proteasome degrades ubiquitinated Rac1, Cdc42
Studies with the mouse mammary epithelial cell line HC11 showed that Cdh1 engagement triggers a dramatic surge in total Rac1 and Cdc42 protein levels and activity through inhibition of proteolytic degradation by the 26S proteasome (Arulanandam et al. 2009, Arulanandam et al. 2010).
Literature References
PubMed ID Title Journal Year
19852956 Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration

Arulanandam, R, Geletu, M, Feracci, H, Raptis, L

Exp Cell Res 2010
19671682 Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3

Arulanandam, R, Vultur, A, Cao, J, Carefoot, E, Elliott, BE, Truesdell, PF, Larue, L, Feracci, H, Raptis, L

Mol Cancer Res 2009
Participants
Input
Output
Catalyst Activity

endopeptidase activity of m26S Proteasome [cytosol]

Physical Entity
m26S Proteasome [cytosol] (Mus musculus)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
26S proteasome degrades ubiquitinated RAC1, CDC42 (Homo sapiens)
Authored
Adan, H  (2025-05-25)
Daniel, J  (2025-05-25)
Raptis, L  (2025-05-25)
Reviewed
Raptis, L  (2025-11-21)
Created
Orlic-Milacic, M  (2026-03-03)
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