IL6 binds IL6R-2

Stable Identifier
R-HSA-1067640
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-6 binds soluble IL6 receptor
ReviewStatus
5/5
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IL6 binds IL6R-2
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The short, soluble form of Interleukin-6 receptor alpha (IL6R-2, sIL6R), like the longer membrane-associated form IL6R, binds circulating Interleukin-6 (IL6). IL6R-2 is generated by limited proteolysis of the longer membrane associated form and by translation of an alternatively spliced mRNA. The IL6:IL6R-2 dimer can associate with the IL6 receptor signaling beta subunit IL6ST (gp130) and stimulate cells that do not express IL6R, a process termed trans-signaling. IL6ST is expressed in many cell types that do not express IL6R (Rose-John et al. 2006).
Literature References
PubMed ID Title Journal Year
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y

Cell 1989
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Orthologous Events
IL6 binds IL6R-2 (Bos taurus)
IL6 binds IL6R-2 (Canis familiaris)
IL6 binds IL6R-2 (Danio rerio)
IL6 binds IL6R-2 (Gallus gallus)
IL6 binds IL6R-2 (Mus musculus)
IL6 binds IL6R-2 (Rattus norvegicus)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-11-26)
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