IL6ST is tyrosine phosphorylated

Stable Identifier
R-HSA-1112510
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
Phosphorylation of gp130
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL6ST is tyrosine phosphorylated
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of IL6ST (gp130) (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the factors STAT1 and STAT3. Several phosphotyrosine residues of IL6ST are docking sites for STATs (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.
Literature References
PubMed ID Title Journal Year
7812050 Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes

Fuller, GM, Wang, Y

Mol Biol Cell 1994
16868551 Tracking STAT nuclear traffic

Reich, NC, Liu, L

Nat Rev Immunol 2006
Participants
Input
Output
Participates
as an event of
Orthologous Events
IL6ST is tyrosine phosphorylated (Bos taurus)
IL6ST is tyrosine phosphorylated (Canis familiaris)
IL6ST is tyrosine phosphorylated (Danio rerio)
IL6ST is tyrosine phosphorylated (Gallus gallus)
IL6ST is tyrosine phosphorylated (Mus musculus)
IL6ST is tyrosine phosphorylated (Rattus norvegicus)
IL6ST is tyrosine phosphorylated (Sus scrofa)
IL6ST is tyrosine phosphorylated (Xenopus tropicalis)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-12-03)
Cite Us!