IL6ST is tyrosine phosphorylated

Stable Identifier
R-HSA-1112510
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of gp130
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of IL6ST (gp130) (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the factors STAT1 and STAT3. Several phosphotyrosine residues of IL6ST are docking sites for STATs (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.

Literature References
PubMed ID Title Journal Year
16868551 Tracking STAT nuclear traffic

Reich, NC, Liu, L

Nat Rev Immunol 2006
7812050 Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes

Wang, Y, Fuller, GM

Mol Biol Cell 1994
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created