The complex of interleukin-6 (IL6) and the soluble, short form of the IL6 receptor (IL6R-2) binds to surface expressed IL6ST (gp130), a process known as trans signaling (Rose-John et al. 2006). This process is negatively regulated by the soluble form of IL6ST (IL6ST-2).
Kishimoto, T, Taga, T, Murakami, M, Hirano, T, Saito, M, Hibi, M
Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y
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