IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Stable Identifier
R-HSA-1067651
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
IL6:sIL6R binds to JAKs:IL6RB (gp130)
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The complex of interleukin-6 (IL6) and the soluble, short form of the IL6 receptor (IL6R-2) binds to surface expressed IL6ST (gp130), a process known as trans signaling (Rose-John et al. 2006). This process is negatively regulated by the soluble form of IL6ST (IL6ST-2).
Literature References
PubMed ID Title Journal Year
2261637 Molecular cloning and expression of an IL-6 signal transducer, gp130

Kishimoto, T, Taga, T, Murakami, M, Hirano, T, Saito, M, Hibi, M

Cell 1990
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y

Cell 1989
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
Orthologous Events
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-11-26)
Cite Us!