Reactome | IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Stable Identifier

R-HSA-1067651

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

IL6:sIL6R binds to JAKs:IL6RB (gp130)

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IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

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The complex of interleukin-6 (IL6) and the soluble, short form of the IL6 receptor (IL6R-2) binds to surface expressed IL6ST (gp130), a process known as trans signaling (Rose-John et al. 2006). This process is negatively regulated by the soluble form of IL6ST (IL6ST-2).

Literature References

PubMed ID	Title	Journal	Year
2788034	Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Taga, T, Hibi, M, Hirata, Y, Yamasaki, K, Yasukawa, K, Matsuda, T, Hirano, T, Kishimoto, T	Cell	1989
2261637	Molecular cloning and expression of an IL-6 signal transducer, gp130 Hibi, M, Murakami, M, Saito, M, Hirano, T, Taga, T, Kishimoto, T	Cell	1990