IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Stable Identifier
R-HSA-1067651
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
IL6:sIL6R binds to JAKs:IL6RB (gp130)
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IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
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The complex of interleukin-6 (IL6) and the soluble, short form of the IL6 receptor (IL6R-2) binds to surface expressed IL6ST (gp130), a process known as trans signaling (Rose-John et al. 2006). This process is negatively regulated by the soluble form of IL6ST (IL6ST-2).

Literature References
PubMed ID Title Journal Year
2261637 Molecular cloning and expression of an IL-6 signal transducer, gp130

Kishimoto, T, Taga, T, Murakami, M, Hirano, T, Saito, M, Hibi, M

Cell 1990
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Matsuda, T, Kishimoto, T, Taga, T, Yamasaki, K, Hirano, T, Hibi, M, Yasukawa, K, Hirata, Y

Cell 1989
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
Orthologous Events
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Danio rerio)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Rattus norvegicus)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-11-26)
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