Reactome | Tyrosine phosphorylation of STAT3 by IL6 receptor

Tyrosine phosphorylation of STAT3 by IL6 receptor

Stable Identifier

R-HSA-9958871

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Tyrosine phosphorylation of STAT3 by IL6 receptor

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Interleukin-6 (IL6) activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by receptor-associated JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT3 this is tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the STAT dimers bind to enhancers of IL6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.

Literature References

PubMed ID	Title	Journal	Year
8626374	Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction Kaptein, A, Paillard, V, Saunders, M	J Biol Chem	1996
8140422	Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 Zhong, Z, Wen, Z, Darnell JE, Jr	Science	1994
7512451	Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway Akira, S, Nishio, Y, Inoue, M, Wang, XJ, Wei, S, Matsusaka, T, Yoshida, K, Sudo, T, Naruto, M, Kishimoto, T	Cell	1994
7510216	Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr	Cell	1994