CDH1 forms cis-clusters

Stable Identifier
R-HSA-9934411
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CDH1 forms cis-clusters
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CDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers engaging laterally, through extracellular domains, with CDH1 molecule(s) expressed in the same cell in a calcium-independent and catenin-independent manner (Chitaev and Troyanovsky 1998). Using super-resolution microscopy techniques it was found that loosely organized cis-clusters of approximately five CDH1 molecules form, that are delimited by the cortical F-actin meshwork, and that serve as the precursors of trans-ligated adhesive clusters that make up the adherens junction (Wu et al. 2015; reviewed in Zhang et al. 2023).
Literature References
PubMed ID Title Journal Year
9700170 Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation

Chitaev, NA, Troyanovsky, SM

J Cell Biol 1998
25600236 Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions

Wu, Y, Kanchanawong, P, Zaidel-Bar, R

Dev Cell 2015
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Orthologous Events
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Authored
Orlic-Milacic, M  (2022-09-15)
Reviewed
Raptis, L  (2025-11-21)
Created
Orlic-Milacic, M  (2025-01-08)
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