Reactome | FAD attaches to SDHA

FAD attaches to SDHA

Stable Identifier

R-HSA-9854672

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Flavin adenine dinucleotide (FAD) binds covalently and non-enzymatically to succinate dehydrogenase complex II (SDH) subunit A (SDHA). The exact mechanism is unclear but depends on the presence of succinate dehydrogenase assembly factor 2 (SDHAF2, SDA5). Fumarate enhances the process (Hao et al., 2009; Maklashina et al., 2022).

Literature References

PubMed ID	Title	Journal	Year
19628817	SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma Schiffman, JD, Schraders, M, Rutter, J, Gygi, SP, Devilee, P, Kunst, H, Bentz, BG, Kremer, H, Dephoure, N, Winge, DR, Hao, HX, Cremers, CW, Bayley, JP, Khalimonchuk, O	Science	2009
36089066	How an assembly factor enhances covalent FAD attachment to the flavoprotein subunit of complex II Cecchini, G, Maklashina, E, Iverson, TM	J Biol Chem	2022