Reactome | SIRT3 [nucleoplasm]

SIRT3 [nucleoplasm]

Stable Identifier

R-HSA-9622879

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NTG7 SIRT3

Gene Names

SIRT3, SIR2L3

Chain

transit peptide:1-, chain:-399

Reference Genes

BioGPS Gene:23410 SIRT3

COSMIC (genes):SIRT3 SIRT3

CTD Gene:23410 SIRT3

dbSNP Gene:23410 SIRT3

ENSEMBL:ENSG00000142082 SIRT3

ENSEMBL_homo_sapiens_GENE:ENSG00000142082.15 SIRT3

HGNC:14931 SIRT3

KEGG Gene (Homo sapiens):23410 SIRT3

Monarch:23410 SIRT3

NCBI Gene:23410 SIRT3

OMIM:604481 SIRT3

UCSC:Q9NTG7 SIRT3

Reference Transcript

Other Identifiers

11722446_a_at

11722447_a_at

11739810_x_at

11739811_a_at

221562_PM_s_at

221562_s_at

221913_PM_at

221913_at

23410

3357786

3357789

3357790

3357796

3357798

3357801

3357804

3357805

3357810

3357811

3357812

3357813

3357815

49325_at

49327_PM_at

49327_at

7945357

A_23_P139265

A_24_P85158

A_24_P923684

GE58473

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0006091

GO:0006325

GO:0006338

GO:0006476

GO:0006629

GO:0008270

GO:0009060

GO:0016740

GO:0016787

GO:0017136

GO:0019899

GO:0023052

GO:0032024

GO:0032991

GO:0033558

GO:0034979

GO:0034983

GO:0036211

GO:0043226

GO:0043565

GO:0046872

GO:0051287

GO:0070373

GO:0070403

GO:0140096

GO:1901671

GO:1902553

GO:2000304

GO:2000378

HMNXSV003049799

Hs.19306.1.S1_3p_s_at

ILMN_1724372

ILMN_1733985

PH_hs_0026684

TC11001228.hg

g13259626_3p_a_at

g13259626_3p_x_at

Participates

as a member of

SIRT1,SIRT3 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

Other forms of this molecule

SIRT3(?-399) [mitochondrial matrix]

Inferred To

SIRT3 [nucleoplasm] (Bos taurus)

SIRT3 [nucleoplasm] (Canis familiaris)

SIRT3 [nucleoplasm] (Gallus gallus)

SIRT3 [nucleoplasm] (Mus musculus)

SIRT3 [nucleoplasm] (Rattus norvegicus)

SIRT3 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001017524.1, NP_036371.1, XP_016872919.1

ZINC - World Drugs

SIR3_HUMAN

Guide to Pharmacology - Targets

2709

OpenTargets

ENSG00000142082

ZINC - FDA approved

SIR3_HUMAN

ZINC - Substances

SIR3_HUMAN

ZINC target

Q9NTG7

ZINC - Biogenic

SIR3_HUMAN

PRO

Q9NTG7

PDB

6ISO, 4JSR, 3GLT, 3GLS, 8HLW, 8HLY, 4C7B, 3GLR, 4JT8, 4HD8, 4BVH, 5Y4H, 5D7N, 4BVG, 4JT9, 4C78, 8ANC, 4BVF, 4O8Z, 8CCW, 4BVE, 5Z93, 8CCZ, 5BWN, 5Z94, 4BVB, 4FZ3, 5BWO, 4FVT, 8HN9, 5ZGC, 8BBK, 5H4D, 4BN5, 5YTK, 3GLU, 8V15, 4BV3, 8V2N, 4BN4

ZINC - Metabolites

SIR3_HUMAN

HPA

ENSG00000142082-SIRT3

GeneCards

Q9NTG7

Ensembl

ENST00000529382, ENST00000382743, ENSP00000372191, ENSP00000437216, ENSG00000142082

Pharos - Targets

Q9NTG7

ZINC - Predictions - Purchasable

SIR3_HUMAN

HMDB Protein

HMDBP08881

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.731	5
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.576	5
UniProt:P28799-2 GRN			0.556	3
UniProt:O60313 OPA1	4	OPA1 [mitochondrial inner membrane] (R-HSA-5333636) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1 [mitochondrial inner membrane] (R-HSA-8867508)	0.544	3
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	4
UniProt:Q9BYZ8 REG4			0.527	2
UniProt:Q96BQ3 TRI43			0.527	2
UniProt:Q9Y6G3 MRPL42	1	MRPL42 [mitochondrial inner membrane] (R-HSA-5368237)	0.527	2
UniProt:P00966 ASS1	1	ASS1 [cytosol] (R-HSA-70574)	0.527	2
UniProt:Q9BX40 LS14B			0.527	2
UniProt:P31040 SDHA	2	FAD-SDHA [mitochondrial matrix] (R-HSA-70983) SDHA [mitochondrial matrix] (R-HSA-9854690)	0.527	2
UniProt:P25705 ATP5F1A	3	ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978) ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5F1A [mitochondrial matrix] (R-HSA-164575)	0.524	2

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