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class I MHC B7 [early endosome membrane]
Stable Identifier
R-HSA-1236872
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Endosomal/Vacuolar pathway (Homo sapiens)
Loading of antigen peptide onto MHC class I molecule (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
class I MHC B7 [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
class I MHC B7 [early endosome membrane] (Homo sapiens)
Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
class I MHC B7 [early endosome membrane] (Homo sapiens)
Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)
IRAP in complex with MHC class I [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
class I MHC B7 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01889 HLA-B
Gene Names
HLA-B, HLAB
Chain
signal peptide:1-24, chain:25-362
Reference Genes
BioGPS Gene:3106 HLA-B
COSMIC (genes):HLA-B HLA-B
CTD Gene:3106 HLA-B
dbSNP Gene:3106 HLA-B
ENSEMBL:ENSG00000234745 HLA-B
HGNC:4932 HLA-B
KEGG:hsa:3106 HLA-B
Monarch:3106 HLA-B
NCBI Gene:3106 HLA-B
UCSC:P01889 HLA-B
Reference Transcript
RefSeq:NM_005514.7 HLA-B
Other Identifiers
11755933_x_at
11755966_x_at
11762851_at
17017147
17034254
17041800
208729_PM_x_at
208729_x_at
209140_3p_x_at
209140_PM_x_at
209140_x_at
2900985
2901110
2901120
2901160
2901170
2901220
2948908
2948910
2948911
2948931
2948932
2948933
2948934
2948935
2948936
2948937
2948938
2948939
2948940
2948941
2948942
2948943
2948944
2948946
2948947
2948948
2948949
2948950
2948951
2948952
2948953
2948956
2948957
2948958
2948976
2948978
2948980
2948984
3106
57280_f_at
8124911
8178498
8179731
A_33_P3242688
A_33_P3379947
D49824_s_at
GE502804
GE695172
GO:0000139
GO:0001916
GO:0002250
GO:0002376
GO:0002474
GO:0002476
GO:0002486
GO:0002667
GO:0005102
GO:0005515
GO:0005615
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006952
GO:0006955
GO:0009897
GO:0009986
GO:0012507
GO:0016020
GO:0016045
GO:0019882
GO:0030667
GO:0030670
GO:0031901
GO:0032655
GO:0032675
GO:0042270
GO:0042605
GO:0042612
GO:0043226
GO:0045087
GO:0046977
GO:0051087
GO:0055038
GO:0070062
GO:0098542
GO:0098553
GO:2001198
HMNXSV003002627
HMNXSV003013706
HMNXSV003021728
HMNXSV003046069
HMNXSV003051457
ILMN_1778401
PH_hs_0031338
TC06004060.hg
TC6_cox_hap2000237.hg
g1871135_3p_x_at
g307236_3p_x_at
g804748_3p_at
g804748_3p_x_at
Participates
as a member of
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
Other forms of this molecule
class I MHC B7 [lumenal side of endoplasmic reticulum membrane]
class I MHC B7 [secretory granule membrane]
class I MHC B7 [plasma membrane]
class I MHC B7 [Golgi membrane]
class I MHC B7 [ER to Golgi transport vesicle membrane]
class I MHC B7 [recycling endosome membrane]
class I MHC B7 [phagocytic vesicle membrane]
Inferred To
H2-T3 [early endosome membrane]
(Mus musculus)
H2-Q10 [early endosome membrane]
(Mus musculus)
RT1-M1-5 [early endosome membrane]
(Rattus norvegicus)
RT1-CE16 [early endosome membrane]
(Rattus norvegicus)
H2-M5 [early endosome membrane]
(Mus musculus)
H2-T22 [early endosome membrane]
(Mus musculus)
mhc1zba [early endosome membrane]
(Danio rerio)
RT1-M1-4 [early endosome membrane]
(Rattus norvegicus)
H2-Q1 [early endosome membrane]
(Mus musculus)
RT1-M10-1 [early endosome membrane]
(Rattus norvegicus)
mhc1zca [early endosome membrane]
(Danio rerio)
DLA-12 [early endosome membrane]
(Canis familiaris)
H2-Q2 [early endosome membrane]
(Mus musculus)
H2-M10.2 [early endosome membrane]
(Mus musculus)
RT1-S3 [early endosome membrane]
(Rattus norvegicus)
SLA-3 [early endosome membrane]
(Sus scrofa)
RT1-CE14 [early endosome membrane]
(Rattus norvegicus)
LOC119876868 [early endosome membrane]
(Canis familiaris)
RT1-N3 [early endosome membrane]
(Rattus norvegicus)
RT1-O1l1 [early endosome membrane]
(Rattus norvegicus)
H2-M10.1 [early endosome membrane]
(Mus musculus)
RT1-M5 [early endosome membrane]
(Rattus norvegicus)
SLA-2 [early endosome membrane]
(Sus scrofa)
H2-D1 [early endosome membrane]
(Mus musculus)
H2-M1 [early endosome membrane]
(Mus musculus)
H2-M9 [early endosome membrane]
(Mus musculus)
DLA88 [early endosome membrane]
(Canis familiaris)
mhc1zea [early endosome membrane]
(Danio rerio)
BFIV21 [early endosome membrane]
(Gallus gallus)
H2-M10.4 [early endosome membrane]
(Mus musculus)
BF1 [early endosome membrane]
(Gallus gallus)
SLA-8 [early endosome membrane]
(Sus scrofa)
AABR07044362.1 [early endosome membrane]
(Rattus norvegicus)
ENSRNOG00000064836 [early endosome membrane]
(Rattus norvegicus)
ENSRNOG00000069480 [early endosome membrane]
(Rattus norvegicus)
mhc1zfa [early endosome membrane]
(Danio rerio)
H2-M10.3 [early endosome membrane]
(Mus musculus)
H2-Q4 [early endosome membrane]
(Mus musculus)
mhc1uma [early endosome membrane]
(Danio rerio)
RT1-CE2 [early endosome membrane]
(Rattus norvegicus)
SLA-7 [early endosome membrane]
(Sus scrofa)
H2-K1 [early endosome membrane]
(Mus musculus)
H2-M3 [early endosome membrane]
(Mus musculus)
H2-M10.6l [early endosome membrane]
(Rattus norvegicus)
RT1-CE10 [early endosome membrane]
(Rattus norvegicus)
class I MHC B7 [early endosome membrane]
(Bos taurus)
class I MHC B7 [early endosome membrane]
(Canis familiaris)
class I MHC B7 [early endosome membrane]
(Gallus gallus)
class I MHC B7 [early endosome membrane]
(Mus musculus)
class I MHC B7 [early endosome membrane]
(Sus scrofa)
AABR07044308.2 [early endosome membrane]
(Rattus norvegicus)
SLA-6 [early endosome membrane]
(Sus scrofa)
RT1-CE1 [early endosome membrane]
(Rattus norvegicus)
H2-Q7 [early endosome membrane]
(Mus musculus)
LOC100513601 [early endosome membrane]
(Sus scrofa)
H2-M10.6 [early endosome membrane]
(Mus musculus)
mhc1uba [early endosome membrane]
(Danio rerio)
Homologues of class I MHC B7 [early endosome membrane]
(Bos taurus)
Homologues of class I MHC B7 [early endosome membrane]
(Canis familiaris)
Homologues of class I MHC B7 [early endosome membrane]
(Danio rerio)
Homologues of class I MHC B7 [early endosome membrane]
(Gallus gallus)
Homologues of class I MHC B7 [early endosome membrane]
(Mus musculus)
Homologues of class I MHC B7 [early endosome membrane]
(Rattus norvegicus)
Homologues of class I MHC B7 [early endosome membrane]
(Sus scrofa)
RT1-M1-2 [early endosome membrane]
(Rattus norvegicus)
H2-M11 [early endosome membrane]
(Mus musculus)
H2-M2 [early endosome membrane]
(Mus musculus)
H2-T23 [early endosome membrane]
(Mus musculus)
mhc1zda [early endosome membrane]
(Danio rerio)
mhc1laa [early endosome membrane]
(Danio rerio)
DLA-79 [early endosome membrane]
(Canis familiaris)
RT1-M2 [early endosome membrane]
(Rattus norvegicus)
H2-Q6 [early endosome membrane]
(Mus musculus)
RT1-M3-1 [early endosome membrane]
(Rattus norvegicus)
H2-M10.5 [early endosome membrane]
(Mus musculus)
Cross References
RefSeq
NP_005505.2
OpenTargets
ENSG00000234745
ENSEMBL
ENSP00000512718
,
ENSP00000512719
,
ENSP00000512717
,
ENST00000696559
,
ENST00000412585
,
ENSP00000512720
,
ENST00000696562
,
ENST00000696561
,
ENST00000696560
,
ENSP00000399168
HPA
ENSG00000234745-HLA-B
PRO
P01889
Pharos - Targets
P01889
GlyGen
P01889
PDB
1JGE
,
3L3K
,
3WUW
,
3L3I
,
7S8A
,
5V5M
,
4U1S
,
1AGD
,
7LFZ
,
3VFT
,
4MJI
,
5VUF
,
5T6Y
,
3W39
,
6D29
,
3FFC
,
3MV8
,
3BWA
,
1E28
,
1W0W
,
5XOS
,
6PYJ
,
3LKP
,
7RZD
,
1A1O
,
6UJ7
,
5VWF
,
2HJL
,
6BXQ
,
1JGD
,
3LN5
,
3SKO
,
6P2F
,
5V5L
,
3VH8
,
4QRP
,
7S8F
,
1ZHL
,
4XXC
,
5EO0
,
4G8G
,
4U1L
,
3VFU
,
3B6S
,
1E27
,
6MT5
,
5IB4
,
4QRS
,
5IND
,
1A1N
,
5B39
,
6BJ8
,
2NW3
,
3D18
,
1N2R
,
3LKR
,
6BXP
,
6UJ9
,
4LNR
,
7S79
,
3DTX
,
4JQV
,
2BSR
,
4U1H
,
5IB3
,
6AVF
,
5T6X
,
3SPV
,
1UXS
,
7S8E
,
1AGC
,
6PYL
,
3MV9
,
6MT4
,
3KPP
,
3UPR
,
3CZF
,
3BP4
,
1W0V
,
3LKQ
,
5WMQ
,
6MTL
,
6PYW
,
5EO1
,
1A1M
,
5B38
,
4G9D
,
1MI5
,
4QRU
,
1A9E
,
5IEK
,
2H6P
,
1ZSD
,
2RFX
,
1OGT
,
7LGT
,
3L3D
,
6P2S
,
2NX5
,
5WMP
,
1SYV
,
5T6W
,
1XH3
,
1ZHK
,
3DXA
,
4U1I
,
4LCY
,
4G8I
,
1OF2
,
4U1M
,
6PYV
,
3LKN
,
2A83
,
3VFV
,
6BJ3
,
4QRT
,
3KPQ
,
3KPL
,
5VWH
,
3LKS
,
2AK4
,
3C9N
,
6P2C
,
1SYS
,
3VCL
,
6AVG
,
3DX7
,
5IB2
,
1AGB
,
3SKM
,
1XR9
,
4JQX
,
3DX6
,
4U1J
,
4PR5
,
3VFW
,
4U1N
,
3VRI
,
6MT3
,
3X11
,
4QRQ
,
6D2B
,
6BJ2
,
3KPM
,
2AXG
,
3KPR
,
3SJV
,
5VWJ
,
6D2T
,
8TUB
,
2BST
,
4O2C
,
3LV3
,
5VUE
,
5WMO
,
3X14
,
1AGF
,
6P23
,
5IM7
,
5IB1
,
1XR8
,
3KXF
,
3VRJ
,
3LKO
,
2BVQ
,
3BW9
,
5DEG
,
3KPS
,
3KPN
,
3BP7
,
7S7E
,
6P27
,
4PRN
,
1A9B
,
5IEH
,
3B3I
,
3HCV
,
4G9F
,
2BSS
,
5U98
,
4O2E
,
2YPK
,
3DX8
,
3L3G
,
6VMX
,
3MV7
,
5T6Z
,
3VFS
,
7S7F
,
4QRR
,
3X12
,
1K5N
,
5INC
,
2BVP
,
1UXW
,
5DEF
,
5IB5
,
2AXF
,
5TXS
,
1M05
,
5T70
,
3KPO
,
6D2R
,
3LN4
,
3L3J
,
5VUD
,
4O2F
,
2YPL
,
1AGE
,
7LGD
,
4U1K
,
5XOT
,
1CG9
,
8TUH
,
5WMN
,
6AT5
,
2BVO
,
6MTM
,
5WMR
,
6MT6
,
7RZJ
,
1M6O
,
6PZ5
,
5VZ5
,
3X13
,
7S7D
,
5VWD
,
6UJ8
,
7LG0
,
3KWW
,
1HSA
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [plasma membrane]
(R-HSA-167743)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
0.93
16
UniProt:P31040 SDHA
2
FAD-SDHA [mitochondrial matrix]
(R-HSA-70983)
SDHA [mitochondrial matrix]
(R-HSA-9854690)
0.564
2
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