Reactome | p-S145,S149-FBXO5 [nucleoplasm]

p-S145,S149-FBXO5 [nucleoplasm]

Stable Identifier

R-HSA-174220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-Emi1(Ser 145, Ser 149)

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Phosphorylation of Emi1 (Homo sapiens)
        
        Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)
        
        phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)
        
        p-S145,S149-FBXO5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UKT4 FBXO5

Gene Names

FBXO5, EMI1, FBX5

Chain

chain:1-447

Reference Genes

BioGPS Gene:26271 FBXO5

COSMIC (genes):FBXO5 FBXO5

CTD Gene:26271 FBXO5

dbSNP Gene:26271 FBXO5

ENSEMBL:ENSG00000112029 FBXO5

ENSEMBL_homo_sapiens_GENE:ENSG00000112029.10 FBXO5

HGNC:13584 FBXO5

KEGG Gene (Homo sapiens):26271 FBXO5

Monarch:26271 FBXO5

NCBI Gene:26271 FBXO5

OMIM:606013 FBXO5

UCSC:Q9UKT4 FBXO5

Reference Transcript

Other Identifiers

11724963_s_at

17024980

218875_PM_s_at

218875_s_at

234863_PM_x_at

234863_x_at

26271

2980242

2980243

2980244

2980245

2980246

2980248

2980250

2980251

2980252

2980254

2980255

2980256

2980257

48490_at

8130374

A_23_P8241

A_33_P3384871

GE58468

GO:0000278

GO:0001556

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0006260

GO:0006275

GO:0006974

GO:0007010

GO:0007049

GO:0007057

GO:0007059

GO:0007088

GO:0007346

GO:0008284

GO:0010948

GO:0010971

GO:0010997

GO:0016050

GO:0016567

GO:0019901

GO:0022414

GO:0030154

GO:0032876

GO:0036211

GO:0040020

GO:0043226

GO:0045669

GO:0045835

GO:0045841

GO:0046785

GO:0046872

GO:0048856

GO:0048870

GO:0051225

GO:0051301

GO:0051444

GO:0065003

GO:0070169

GO:0072687

GO:0098772

GO:0140013

GO:0140014

GO:0140678

GO:1904667

GO:1905322

GO:1990948

GO:2000773

HMNXSV003041192

Hs.272027.1.S1_3p_s_at

ILMN_1710676

ILMN_2121555

PH_hs_0014007

TC06002240.hg

Participates

as a component of

phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S182-FBXO5 [cytosol]

p-S145,S149-FBXO5 [cytosol]

FBXO5 [nucleoplasm]

p-S182-FBXO5 [nucleoplasm]

p-FBXO5 [nucleoplasm]

Inferred To

phospho-Rca1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S145,S149-FBXO5 [nucleoplasm] (Danio rerio)

phospho-p-S145,S149-FBXO5 [nucleoplasm] (Gallus gallus)

phospho-p-S145,S149-FBXO5 [nucleoplasm] (Mus musculus)

phospho-p-S145,S149-FBXO5 [nucleoplasm] (Rattus norvegicus)

phospho-FBXO5 [nucleoplasm] (Bos taurus)

phospho-FBXO5 [nucleoplasm] (Canis familiaris)

phospho-FBXO5 [nucleoplasm] (Sus scrofa)

phospho-fbxo5 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 145

Coordinate

145

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 149

Coordinate

149

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_036309.1, NP_001135994.1

OpenTargets

ENSG00000112029

GeneCards

Q9UKT4

HPA

ENSG00000112029-FBXO5

Ensembl

ENST00000229758, ENSG00000112029, ENST00000367241, ENSP00000356210, ENSP00000229758

PRO

Q9UKT4

Pharos - Targets

Q9UKT4

PDB

4UI9, 7QE7, 2M6N, 8S4G

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.801	8
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.669	3
UniProt:O60447 EVI5			0.645	6
UniProt:Q8NHZ8 CDC26	2	CDC26 [nucleoplasm] (R-HSA-174216) CDC26 [cytosol] (R-HSA-174052)	0.643	4
UniProt:Q13042 CDC16	2	CDC16 [nucleoplasm] (R-HSA-174049) CDC16 [cytosol] (R-HSA-174156)	0.643	3
UniProt:Q8BGZ4	2	Cdc23 [nucleoplasm] (R-MMU-174228) Cdc23 [cytosol] (R-MMU-174137)	0.564	3
UniProt:Q8R349	2	Cdc16 [nucleoplasm] (R-MMU-174049) Cdc16 [cytosol] (R-MMU-174156)	0.564	3
UniProt:Q99JP4	2	Cdc26 [nucleoplasm] (R-MMU-174216) Cdc26 [cytosol] (R-MMU-174052)	0.564	2
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.527	2
UniProt:Q96DE5 ANAPC16	2	ANAPC16 [nucleoplasm] (R-HSA-6805137) ANAPC16 [cytosol] (R-HSA-6805138)	0.527	3
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.527	2
UniProt:P60006 ANAPC15	2	ANAPC15 [nucleoplasm] (R-HSA-6805136) ANAPC15 [cytosol] (R-HSA-6805140)	0.527	2
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [nucleoplasm] (R-HSA-174115) ANAPC4 [cytosol] (R-HSA-174168)	0.527	2