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p-S182-FBXO5 [nucleoplasm]
Stable Identifier
R-HSA-176447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-Emi1(Ser 182)
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Phosphorylation of Emi1 (Homo sapiens)
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)
Phospho-Emi1(Ser 182):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)
p-S182-FBXO5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKT4 FBXO5
Gene Names
FBXO5, EMI1, FBX5
Chain
chain:1-447
Reference Genes
BioGPS Gene:26271 FBXO5
COSMIC (genes):FBXO5 FBXO5
CTD Gene:26271 FBXO5
dbSNP Gene:26271 FBXO5
ENSEMBL:ENSG00000112029 FBXO5
ENSEMBL_homo_sapiens_GENE:ENSG00000112029.10 FBXO5
HGNC:13584 FBXO5
KEGG Gene (Homo sapiens):26271 FBXO5
Monarch:26271 FBXO5
NCBI Gene:26271 FBXO5
OMIM:606013 FBXO5
UCSC:Q9UKT4 FBXO5
Reference Transcript
RefSeq:NM_001142522.2 FBXO5
RefSeq:NM_012177.4 FBXO5
Other Identifiers
11724963_s_at
17024980
218875_PM_s_at
218875_s_at
234863_PM_x_at
234863_x_at
26271
2980242
2980243
2980244
2980245
2980246
2980248
2980250
2980251
2980252
2980254
2980255
2980256
2980257
48490_at
8130374
A_23_P8241
A_33_P3384871
GE58468
GO:0000278
GO:0001556
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006260
GO:0006275
GO:0006974
GO:0007010
GO:0007049
GO:0007057
GO:0007059
GO:0007088
GO:0007346
GO:0008284
GO:0010948
GO:0010971
GO:0010997
GO:0016050
GO:0016567
GO:0019901
GO:0022414
GO:0030154
GO:0032876
GO:0036211
GO:0040020
GO:0043226
GO:0045669
GO:0045835
GO:0045841
GO:0046785
GO:0046872
GO:0048856
GO:0048870
GO:0051225
GO:0051301
GO:0051444
GO:0065003
GO:0070169
GO:0072687
GO:0098772
GO:0140013
GO:0140014
GO:0140678
GO:1904667
GO:1905322
GO:1990948
GO:2000773
HMNXSV003041192
Hs.272027.1.S1_3p_s_at
ILMN_1710676
ILMN_2121555
PH_hs_0014007
TC06002240.hg
Participates
as a component of
Phospho-Emi1(Ser 182):Cdc20/Cdh1 complexes [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S182-FBXO5 [cytosol]
p-S145,S149-FBXO5 [cytosol]
FBXO5 [nucleoplasm]
p-S145,S149-FBXO5 [nucleoplasm]
p-FBXO5 [nucleoplasm]
Inferred To
phospho-p-S182-FBXO5 [nucleoplasm]
(Danio rerio)
phospho-p-S182-FBXO5 [nucleoplasm]
(Gallus gallus)
phospho-p-S182-FBXO5 [nucleoplasm]
(Mus musculus)
phospho-p-S182-FBXO5 [nucleoplasm]
(Rattus norvegicus)
phospho-Rca1 [nucleoplasm]
(Drosophila melanogaster)
phospho-FBXO5 [nucleoplasm]
(Bos taurus)
phospho-FBXO5 [nucleoplasm]
(Canis familiaris)
phospho-FBXO5 [nucleoplasm]
(Sus scrofa)
phospho-fbxo5 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 182
Coordinate
182
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_036309.1
,
NP_001135994.1
OpenTargets
ENSG00000112029
GeneCards
Q9UKT4
HPA
ENSG00000112029-FBXO5
Ensembl
ENST00000229758
,
ENSG00000112029
,
ENST00000367241
,
ENSP00000356210
,
ENSP00000229758
PRO
Q9UKT4
Pharos - Targets
Q9UKT4
PDB
4UI9
,
7QE7
,
2M6N
,
8S4G
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.801
8
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.669
3
UniProt:O60447 EVI5
0.645
6
UniProt:Q8NHZ8 CDC26
2
CDC26 [nucleoplasm]
(R-HSA-174216)
CDC26 [cytosol]
(R-HSA-174052)
0.643
4
UniProt:Q13042 CDC16
2
CDC16 [nucleoplasm]
(R-HSA-174049)
CDC16 [cytosol]
(R-HSA-174156)
0.643
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
3
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
3
UniProt:Q99JP4
2
Cdc26 [nucleoplasm]
(R-MMU-174216)
Cdc26 [cytosol]
(R-MMU-174052)
0.564
2
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.527
2
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
ANAPC16 [cytosol]
(R-HSA-6805138)
0.527
3
UniProt:Q9UJX6 ANAPC2
2
ANAPC2 [cytosol]
(R-HSA-174229)
ANAPC2 [nucleoplasm]
(R-HSA-174141)
0.527
2
UniProt:P60006 ANAPC15
2
ANAPC15 [nucleoplasm]
(R-HSA-6805136)
ANAPC15 [cytosol]
(R-HSA-6805140)
0.527
2
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [nucleoplasm]
(R-HSA-174115)
ANAPC4 [cytosol]
(R-HSA-174168)
0.527
2
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