Reactome | SPSB1 [cytosol]

SPSB1 [cytosol]

Stable Identifier

R-DDI-976024

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q54Y77

Locations in the PathwayBrowser

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Metabolism of proteins (Dictyostelium discoideum)

- Post-translational protein modification (Dictyostelium discoideum)
  - Neddylation (Dictyostelium discoideum)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Dictyostelium discoideum)
        
        CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Dictyostelium discoideum)
        
        CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        CUL5-box protein [cytosol] (Dictyostelium discoideum)
        
        SPSB1 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54Y77

Reference Genes

BioGPS Gene:8621531

dictyBase:DDB_G0278671

ENSEMBL:DDB_G0278671

KEGG:ddi:DDB_G0278671

Monarch:8621531

NCBI Gene:8621531

UCSC:Q54Y77

Participates

as a member of

Other forms of this molecule

SPSB3 [cytosol]

SPSB2 [cytosol]

Inferred From

SPSB1 [cytosol] (Homo sapiens)

SPSB4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_642325.1

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