Reactome | FANCI [nucleoplasm]

FANCI [nucleoplasm]

Stable Identifier

R-HSA-419529

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group I protein, FANCI_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        CDK12 stimulates expression of DNA repair genes (Homo sapiens)
        
        BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] (Homo sapiens)
        
        FANCI [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVI1 FANCI

Gene Names

FANCI, KIAA1794

Chain

chain:1-1328

Reference Genes

BioGPS Gene:55215 FANCI

COSMIC (genes):FANCI FANCI

CTD Gene:55215 FANCI

dbSNP Gene:55215 FANCI

ENSEMBL:ENSG00000140525 FANCI

HGNC:25568 FANCI

KEGG Gene (Homo sapiens):55215 FANCI

Monarch:55215 FANCI

NCBI Gene:55215 FANCI

OMIM:611360 FANCI

UCSC:Q9NVI1 FANCI

Reference Transcript

Other Identifiers

0002260072

11729458_a_at

11730875_a_at

11730876_a_at

16804559

213007_at

213008_at

223785_at

32617_at

3607511

3607513

3607514

3607516

3607519

3607520

3607522

3607523

3607524

3607525

3607528

3607529

3607532

3607536

3607538

3607539

3607540

3607541

3607542

3607544

3607545

3607546

3607548

3607549

3607550

3607553

3607556

3607557

3607558

3607559

3607560

3607561

3607565

3607566

3607567

3607569

3607570

3607571

3607572

3607573

3607574

3607575

3607576

3607577

3607579

3607583

3607584

3607585

3607588

3607589

3607590

55215

75018_at

7985829

A_14_P140006

A_23_P375104

A_24_P902509

A_32_P95729

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006464

GO:0006950

GO:0006974

GO:0007049

GO:0008150

GO:0016020

GO:0019899

GO:0031398

GO:0034641

GO:0036297

GO:0043226

GO:0070182

Hs.80961.1.A1_3p_at

Hs.80961.1.A2_3p_at

ILMN_1655642

PH_hs_0016481

TC15000846.hg

g13279100_3p_at

Participant Of

hasMember

BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm]

input

FANCD2 binds FANCI

hasComponent

FANCD2:FANCI [nucleoplasm]

Other forms of this molecule

p-4S-FANCI [nucleoplasm]

MonoUb-K523,p-4S-FANCI [nucleoplasm]

Inferred To

fnci-1 [nucleoplasm] (Caenorhabditis elegans)

fanci [nucleoplasm] (Danio rerio)

fanci [nucleoplasm] (Xenopus tropicalis)

FANCI [nucleoplasm] (Bos taurus)

FANCI [nucleoplasm] (Canis familiaris)

FANCI [nucleoplasm] (Dictyostelium discoideum)

FANCI [nucleoplasm] (Drosophila melanogaster)

FANCI [nucleoplasm] (Gallus gallus)

FANCI [nucleoplasm] (Sus scrofa)

Fanci [nucleoplasm] (Mus musculus)

Fanci [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011520066.1, XP_011520059.1, XP_011520058.1, NP_060663.2, NP_001106849.1

OpenTargets

ENSG00000140525

HPA

ENSG00000140525-FANCI

GeneCards

Q9NVI1

Ensembl

ENSG00000140525, ENSP00000300027, ENST00000567996, ENSP00000458024, ENST00000300027, ENSP00000310842, ENST00000310775

PRO

Q9NVI1

Orphanet

16788

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) FANCD2 [nucleoplasm] (R-HSA-419522)	0.589	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.564	2
IntAct:EBI-4399559 UBIQ			0.558	2
UniProt:Q16658 FSCN1	1	FSCN1 [cytosol] (R-HSA-6789835)	0.532	3