CUL5-box protein [cytosol]

Stable Identifier
R-HSA-8863155
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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General

The CUL5-box was initially identified as the SOCS-box in Suppressor of Cytokine Signaling proteins. It has since been identified in numerous other protiens including the ankyrin and SOCS-box (ASB) proteins and others (Mahrour et al. 2008).

Literature References
PubMed ID Title Journal Year
15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T, Maenaka, K, Kotoshiba, S, Matsumoto, M, Kohda, D, Conaway, RC, Conaway, JW, Nakayama, KI

Genes Dev 2004
11384984 Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase

Kamura, T, Burian, D, Yan, Q, Schmidt, SL, Lane, WS, Querido, E, Branton, PE, Shilatifard, A, Conaway, RC, Conaway, JW

J. Biol. Chem. 2001
16325183 ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

Kohroki, J, Nishiyama, T, Nakamura, T, Masuho, Y

FEBS Lett 2005
18187417 Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases

Mahrour, N, Redwine, WB, Florens, LA, Swanson, SK, Martin-Brown, S, Bradford, WD, Staehling-Hampton, K, Washburn, MP, Conaway, RC, Conaway, JW

J. Biol. Chem. 2008
21145461 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Bennett, EJ, Rush, J, Gygi, SP, Harper, JW

Cell 2010
Participants
members
Participant Of
hasComponent
Inferred To
CUL5-box protein [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Caenorhabditis elegans)
CUL5-box protein [cytosol] (Canis familiaris)
CUL5-box protein [cytosol] (Danio rerio)
CUL5-box protein [cytosol] (Dictyostelium discoideum)
CUL5-box protein [cytosol] (Drosophila melanogaster)
CUL5-box protein [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Sus scrofa)
CUL5-box protein [cytosol] (Xenopus tropicalis)
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