CUL5-box protein [cytosol]

Stable Identifier
R-HSA-8863155
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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General
The CUL5-box was initially identified as the SOCS-box in Suppressor of Cytokine Signaling proteins. It has since been identified in numerous other protiens including the ankyrin and SOCS-box (ASB) proteins and others (Mahrour et al. 2008).
Literature References
PubMed ID Title Journal Year
11384984 Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase

Conaway, RC, Lane, WS, Burian, D, Conaway, JW, Shilatifard, A, Branton, PE, Querido, E, Kamura, T, Schmidt, SL, Yan, Q

J. Biol. Chem. 2001
21145461 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Bennett, EJ, Gygi, SP, Rush, J, Harper, JW

Cell 2010
15601820 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kotoshiba, S, Kamura, T, Kohda, D, Maenaka, K, Nakayama, KI, Conaway, JW, Conaway, RC, Matsumoto, M

Genes Dev 2004
16325183 ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes

Masuho, Y, Nakamura, T, Kohroki, J, Nishiyama, T

FEBS Lett 2005
18187417 Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases

Bradford, WD, Redwine, WB, Martin-Brown, S, Conaway, RC, Staehling-Hampton, K, Florens, LA, Mahrour, N, Conaway, JW, Swanson, SK, Washburn, MP

J. Biol. Chem. 2008
Participants
members
Participates
as a component of
Inferred To
CUL5-box protein [cytosol] (Bos taurus)
CUL5-box protein [cytosol] (Caenorhabditis elegans)
CUL5-box protein [cytosol] (Canis familiaris)
CUL5-box protein [cytosol] (Danio rerio)
CUL5-box protein [cytosol] (Dictyostelium discoideum)
CUL5-box protein [cytosol] (Drosophila melanogaster)
CUL5-box protein [cytosol] (Gallus gallus)
CUL5-box protein [cytosol] (Mus musculus)
CUL5-box protein [cytosol] (Rattus norvegicus)
CUL5-box protein [cytosol] (Sus scrofa)
CUL5-box protein [cytosol] (Xenopus tropicalis)
ASB family [cytosol] (Schizosaccharomyces pombe)
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