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EPHB2 [plasma membrane]
Stable Identifier
R-HSA-443809
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-B receptor 2, EPHB2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
MMP2,9 cleave EPHB (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH:EFN dimers tetramerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH:EFN tetramers oligomerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs bind EFNBs (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EFNBs bind SDCBP (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SDCBP [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EFNBs bind SFKs (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
SFKs phosphorylate GIT1 (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
L1CAM interactions (Homo sapiens)
Phosphorylation of L1 by EPHB2 (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
p-Y-L1:EPHB2 [plasma membrane] (Homo sapiens)
EPHB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29323 EPHB2
Gene Names
EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5
Chain
signal peptide:1-18, chain:19-1055, chain:536-986, chain:562-986
Reference Genes
BioGPS Gene:2048 EPHB2
COSMIC (genes):EPHB2 EPHB2
CTD Gene:2048 EPHB2
dbSNP Gene:2048 EPHB2
ENSEMBL:ENSG00000133216 EPHB2
ENSEMBL_homo_sapiens_GENE:ENSG00000133216.17 EPHB2
HGNC:3393 EPHB2
KEGG Gene (Homo sapiens):2048 EPHB2
Monarch:2048 EPHB2
NCBI Gene:2048 EPHB2
OMIM:600997 EPHB2
UCSC:P29323 EPHB2
Reference Transcript
RefSeq:NM_001309193.1 EPHB2
RefSeq:NM_004442.7 EPHB2
RefSeq:NM_017449.4 EPHB2
Other Identifiers
11723166_a_at
11723167_at
11723168_a_at
11751035_a_at
16660596
2048
2088_s_at
209588_PM_at
209588_at
209589_PM_s_at
209589_s_at
210651_PM_s_at
210651_s_at
211165_PM_x_at
211165_x_at
230088_PM_at
230088_at
230119_PM_at
230119_at
2324920
2324921
2324922
2324923
2324934
2324939
2324962
2324963
2324965
2324969
2324970
2324971
2324973
2324974
2324977
2324980
2324981
2324982
2324983
2324984
2324985
2324986
2324987
2324988
2324989
2324990
2324991
2324992
2324993
2324994
2324995
2324996
2324997
2324998
2655883
41678_at
46069_at
47096_at
7898809
80277_at
902_at
A_14_P136035
A_23_P200067
A_32_P406142
A_33_P3331376
A_33_P3370787
A_33_P3880302
GE480816
GE54191
GO:0000166
GO:0000902
GO:0001525
GO:0001540
GO:0001655
GO:0001933
GO:0002376
GO:0002639
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005005
GO:0005102
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0006468
GO:0006469
GO:0006914
GO:0006954
GO:0007155
GO:0007162
GO:0007169
GO:0007399
GO:0007409
GO:0007411
GO:0007413
GO:0007611
GO:0007612
GO:0008046
GO:0009887
GO:0009986
GO:0010628
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0021631
GO:0021934
GO:0021952
GO:0022038
GO:0023052
GO:0030154
GO:0030193
GO:0030335
GO:0030424
GO:0030425
GO:0030890
GO:0031290
GO:0031915
GO:0032760
GO:0034330
GO:0036211
GO:0038023
GO:0042060
GO:0042113
GO:0042472
GO:0042734
GO:0042802
GO:0042995
GO:0043025
GO:0043197
GO:0043226
GO:0044877
GO:0045211
GO:0046425
GO:0046580
GO:0048013
GO:0048168
GO:0048170
GO:0048593
GO:0048856
GO:0048870
GO:0050770
GO:0050771
GO:0050877
GO:0050878
GO:0051489
GO:0051963
GO:0051965
GO:0055085
GO:0060021
GO:0060089
GO:0060996
GO:0060997
GO:0061003
GO:0061024
GO:0070373
GO:0071222
GO:0071679
GO:0072659
GO:0097104
GO:0098686
GO:0098794
GO:0098978
GO:0099557
GO:0106028
GO:0110077
GO:0120192
GO:0140096
GO:1900016
GO:1900273
GO:1903078
GO:1904646
GO:1904782
GO:1904783
GO:2000010
GO:2000316
GO:2000785
GO:2000822
HMNXSV003032720
HMNXSV003057294
Hs.125124.1.S2_3p_at
Hs.147112.0.S1_3p_at
Hs.147112.0.S2_3p_at
ILMN_1785061
ILMN_2367384
L41939_at
PH_hs_0007059
PH_hs_0018535
TC01000288.hg
TC01000291.hg
TC01004238.hg
g1100109_3p_a_at
g2739055_3p_a_at
g495677_3p_a_at
p25682
Participates
as a member of
EPHBs [plasma membrane] (Homo sapiens)
as a component of
p-Y-L1:EPHB2 [plasma membrane] (Homo sapiens)
as an input of
Phosphorylation of L1 by EPHB2 (Homo sapiens)
Other forms of this molecule
EPHB2 (?-?) [plasma membrane]
EPHB2 (?-1055) [cytosol]
EPHB2 (?-1055) [plasma membrane]
EPHB2 (19-?) [extracellular region]
p-Y596,Y602-EPHB2 [plasma membrane]
Inferred To
EPHB2 [plasma membrane]
(Bos taurus)
EPHB2 [plasma membrane]
(Canis familiaris)
EPHB2 [plasma membrane]
(Gallus gallus)
EPHB2 [plasma membrane]
(Mus musculus)
EPHB2 [plasma membrane]
(Rattus norvegicus)
EPHB2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_059145.2
,
NP_001296122.1
,
NP_004433.2
ZINC - World Drugs
EPHB2_HUMAN
Guide to Pharmacology - Targets
1831
OpenTargets
ENSG00000133216
ZINC - FDA approved
EPHB2_HUMAN
ZINC - Substances
EPHB2_HUMAN
ZINC target
P29323
ZINC - Biogenic
EPHB2_HUMAN
PRO
P29323
PDB
1B4F
,
3ZFM
,
8EBL
,
2QBX
,
1F0M
ZINC - Investigational
EPHB2_HUMAN
HPA
ENSG00000133216-EPHB2
GeneCards
P29323
Ensembl
ENSP00000363761
,
ENSP00000383053
,
ENSP00000363763
,
ENSG00000133216
,
ENST00000374632
,
ENST00000374630
,
ENST00000400191
Pharos - Targets
P29323
Orphanet
15984
ZINC - Predictions - Purchasable
EPHB2_HUMAN
HMDB Protein
HMDBP01537
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.544
2
UniProt:P54764 EPHA4
2
EPHA4 [plasma membrane]
(R-HSA-2682325)
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
0.539
3
UniProt:P52799 EFNB2
2
p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(R-HSA-3928387)
EFNB2 [plasma membrane]
(R-HSA-2682330)
0.527
2
UniProt:O75592 MYCB2
0.527
2
UniProt:P0C2W1 FBSP1
0.527
2
UniProt:Q15375 EPHA7
2
EPHA7 [plasma membrane]
(R-HSA-2682337)
p-Y608,Y614-EPHA7 [plasma membrane]
(R-HSA-3928358)
0.499
2
UniProt:P07333 CSF1R
4
PolyUb,p-8Y-CSF1R [plasma membrane]
(R-HSA-389142)
PolyUb,p-Y561-CSF1R [plasma membrane]
(R-HSA-9733335)
p-Y561-CSF1R [plasma membrane]
(R-HSA-9733328)
CSF1R [plasma membrane]
(R-HSA-197667)
0.499
2
UniProt:P29317 EPHA2
2
EPHA2 [plasma membrane]
(R-HSA-211422)
p-Y588,Y594-EPHA2 [plasma membrane]
(R-HSA-3928380)
0.483
3
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