Reactome | EPHB2 (19-?) [extracellular region]

EPHB2 (19-?) [extracellular region]

Stable Identifier

R-HSA-3928436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Ephrin type-B receptor 2, EPHB2_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        MMP2,9 cleave EPHB (Homo sapiens)
        
        EPHB N-terminal fragments [extracellular region] (Homo sapiens)
        
        EPHB2 (19-?) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29323 EPHB2

Gene Names

EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5

Chain

signal peptide:1-18, chain:19-1055, chain:536-986, chain:562-986

Reference Genes

BioGPS Gene:2048 P293233

COSMIC (genes):EPHB2 EPHB2

CTD Gene:2048 P293233

dbSNP Gene:2048 P293233

ENSEMBL:ENSG00000133216 EPHB2

HGNC:3393 P293233

KEGG:hsa:2048 P293233

Monarch:2048 P293233

NCBI Gene:2048 P293233

OMIM:600997 P293233

UCSC:P29323 P293233

Reference Transcript

Participates

as a member of

EPHB N-terminal fragments [extracellular region] (Homo sapiens)

Other forms of this molecule

p-Y596,Y602-EPHB2 [plasma membrane]

EPHB2 [plasma membrane]

EPHB2 (?-1055) [plasma membrane]

EPHB2 (?-1055) [cytosol]

EPHB2 (?-?) [plasma membrane]

Inferred To

EPHB2 (19-?) [extracellular region] (Bos taurus)

EPHB2 (19-?) [extracellular region] (Canis familiaris)

EPHB2 (19-?) [extracellular region] (Gallus gallus)

EPHB2 (19-?) [extracellular region] (Mus musculus)

EPHB2 (19-?) [extracellular region] (Rattus norvegicus)

EPHB2 (19-?) [extracellular region] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1831

OpenTargets

ENSG00000133216

ENSEMBL

ENST00000374632, ENSG00000133216, ENST00000400191, ENST00000374630, ENSP00000363763, ENSP00000363761, ENSP00000383053

ZINC - FDA approved

EPHB2_HUMAN

ZINC - Substances

EPHB2_HUMAN

ZINC - Biogenic

EPHB2_HUMAN

ZINC target

P29323

PRO

P29323

GlyGen

P29323

PDB

3ZFM, 1B4F, 8EBL, 1F0M, 2QBX

ZINC - Investigational

EPHB2_HUMAN

HPA

ENSG00000133216-EPHB2

GeneCards

EPHB2

Pharos - Targets

P29323

Orphanet

EPHB2

ZINC - Predictions - Purchasable

EPHB2_HUMAN

HMDB Protein

HMDBP01537

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.544	2
UniProt:P54764 EPHA4	2	p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352) EPHA4 [plasma membrane] (R-HSA-2682325)	0.539	3
UniProt:P0C2W1 FBSP1			0.527	2
UniProt:O75592 MYCB2			0.527	2
UniProt:P52799 EFNB2	2	p-Y311,Y316,Y330-EFNB2 [plasma membrane] (R-HSA-3928387) EFNB2 [plasma membrane] (R-HSA-2682330)	0.527	2
UniProt:P07333 CSF1R	4	CSF1R [plasma membrane] (R-HSA-197667) p-Y561-CSF1R [plasma membrane] (R-HSA-9733328) PolyUb,p-Y561-CSF1R [plasma membrane] (R-HSA-9733335) PolyUb,p-8Y-CSF1R [plasma membrane] (R-HSA-389142)	0.499	2
UniProt:Q15375 EPHA7	2	p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358) EPHA7 [plasma membrane] (R-HSA-2682337)	0.499	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.483	3

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