Reactome | PTPRZ1 [plasma membrane]

PTPRZ1 [plasma membrane]

Stable Identifier

R-HSA-374561

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RPTPzeta, Receptor-type tyrosine-protein phosphatase zeta, PTPRZ_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23471 PTPRZ1

Gene Names

PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ

Chain

signal peptide:1-24, chain:25-2315

Reference Genes

BioGPS Gene:5803 PTPRZ1

COSMIC (genes):PTPRZ1 PTPRZ1

CTD Gene:5803 PTPRZ1

dbSNP Gene:5803 PTPRZ1

ENSEMBL:ENSG00000106278 PTPRZ1

ENSEMBL_homo_sapiens_GENE:ENSG00000106278.12 PTPRZ1

HGNC:9685 PTPRZ1

KEGG Gene (Homo sapiens):5803 PTPRZ1

Monarch:5803 PTPRZ1

NCBI Gene:5803 PTPRZ1

OMIM:176891 PTPRZ1

OMIM:604008 PTPRZ1

UCSC:P23471 PTPRZ1

Reference Transcript

Other Identifiers

11719443_at

11719444_s_at

11746144_a_at

1364_at

17050847

204469_PM_at

204469_at

3021378

3021379

3021380

3021396

3021408

3021409

3021410

3021411

3021416

3021417

3021419

3021421

3021422

3021424

3021426

3021427

3021428

3021429

3021430

3021431

3021432

3021433

3021434

3021435

3021436

3021437

3021442

3021444

3021446

3021451

3021452

3021453

3021454

3021456

3021457

3021458

3021460

3021461

3021462

3021464

3021466

3021468

3021470

3021471

5803

8135774

A_14_P119963

A_14_P126939

A_23_P168761

A_24_P235248

A_24_P8474

GE58152

GO:0002244

GO:0003824

GO:0004721

GO:0004725

GO:0005001

GO:0005178

GO:0005515

GO:0005576

GO:0005886

GO:0006470

GO:0007409

GO:0007417

GO:0007611

GO:0012501

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0030154

GO:0030312

GO:0031012

GO:0031641

GO:0035335

GO:0036211

GO:0043524

GO:0045202

GO:0048709

GO:0048714

GO:0048856

GO:0050877

GO:0060089

GO:0070445

GO:0072534

GO:0140096

HMNXSV003053121

ILMN_1676616

M93426_at

TC07000738.hg

g4506328_3p_at

Participates

as a component of

IL34 dimer:PTPRZ1 [plasma membrane] (Homo sapiens)

as an input of

IL34 dimer binds PTPRZ1 (Homo sapiens)

Other forms of this molecule

C4S-PTPRZ1 [plasma membrane]

Inferred To

PTPRZ1 [plasma membrane] (Bos taurus)

PTPRZ1 [plasma membrane] (Canis familiaris)

PTPRZ1 [plasma membrane] (Gallus gallus)

PTPRZ1 [plasma membrane] (Mus musculus)

PTPRZ1 [plasma membrane] (Rattus norvegicus)

PTPRZ1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_005250576.1, NP_001193767.1, NP_001193768.1, NP_002842.2

Guide to Pharmacology - Targets

1869

OpenTargets

ENSG00000106278

HPA

ENSG00000106278-PTPRZ1

GeneCards

P23471

Ensembl

ENST00000652298, ENSG00000106278, ENSP00000410000, ENST00000449182, ENST00000393386, ENSP00000377047, ENSP00000499137

PRO

P23471

Pharos - Targets

P23471

HMDB Protein

HMDBP08953

PDB

5H08, 8FN9, 3JXF, 8FN8, 3S97, 5AWX

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12860 CNTN1	1	CNTN1 [plasma membrane] (R-HSA-373622)	0.611	3
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.544	2
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) ITGB3 [plasma membrane] (R-HSA-57600)	0.463	2

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