Reactome | ALK G1269S [plasma membrane]

ALK G1269S [plasma membrane]

Stable Identifier

R-HSA-9701835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ALK tyrosine kinase receptor, ALK_HUMAN

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - ALK mutants bind TKIs (Homo sapiens)
      - ALK mutants bind type I TKIs (Homo sapiens)
        
        type I ALK-binding TKIs:type I-sensitive ALK mutants [cytosol] (Homo sapiens)
        
        type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
        
        NVP-TAE684-sensitive ALK mutants [cytosol] (Homo sapiens)
        
        ALK G1269S dimer [plasma membrane] (Homo sapiens)
        
        ALK G1269S [plasma membrane] (Homo sapiens)
        
        type I TKI sensitive ALK mutants [plasma membrane] (Homo sapiens)
        
        NVP-TAE684-sensitive ALK mutants [cytosol] (Homo sapiens)
        
        ALK G1269S dimer [plasma membrane] (Homo sapiens)
        
        ALK G1269S [plasma membrane] (Homo sapiens)
    - Drug resistance of ALK mutants (Homo sapiens)
      - crizotinib-resistant ALK mutants (Homo sapiens)
        
        crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)
        
        crizotinib resistant ALK mutants [plasma membrane] (Homo sapiens)
        
        ALK G1269S dimer [plasma membrane] (Homo sapiens)
        
        ALK G1269S [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21948233	ALK mutations conferring differential resistance to structurally diverse ALK inhibitors Lovly, CM, Grütter, C, Heynck, S, Sos, ML, Thomas, RK, Peifer, M, Balke-Want, H, Heuckmann, JM, Rauh, D, Koker, M, Weiss, J, Pao, W, Hölzel, M	Clin. Cancer Res.	2011

External Reference Information

External Reference

UniProt:Q9UM73 ALK

Gene Names

ALK

Chain

signal peptide:1-18, chain:19-1620

Reference Genes

BioGPS Gene:238 ALK

COSMIC (genes):ALK ALK

CTD Gene:238 ALK

dbSNP Gene:238 ALK

ENSEMBL:ENSG00000171094 ALK

ENSEMBL_homo_sapiens_GENE:ENSG00000171094.18 ALK

HGNC:427 ALK

KEGG Gene (Homo sapiens):238 ALK

Monarch:238 ALK

NCBI Gene:238 ALK

OMIM:105590 ALK

UCSC:Q9UM73 ALK

Reference Transcript

RefSeq:NM_004304.4 ALK

Other Identifiers

11740853_a_at

11750678_a_at

16896049

208211_PM_s_at

208211_s_at

208212_PM_s_at

208212_s_at

238

2546410

2546411

2546412

2546413

2546414

2546415

2546416

2546417

2546418

2546420

2546423

2546424

2546429

2546431

2546432

2546433

2546434

2546436

2546437

2546439

2546440

2546441

2546442

2546444

2546450

2546458

2546459

2546464

2546468

2546470

2546471

2546472

2546479

2546492

2546493

2546508

2546511

2546512

2546542

2546543

38543_at

451_at

66494_at

8051241

A_23_P10091

A_23_P324304

GE81380

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006629

GO:0007165

GO:0007169

GO:0007399

GO:0007420

GO:0008201

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0021766

GO:0023052

GO:0030154

GO:0030298

GO:0030534

GO:0032991

GO:0036211

GO:0036269

GO:0038083

GO:0042127

GO:0042802

GO:0042981

GO:0043226

GO:0043235

GO:0045664

GO:0046777

GO:0048666

GO:0048856

GO:0050995

GO:0051092

GO:0060089

GO:0060159

GO:0070062

GO:0090648

GO:0097009

GO:0098772

GO:0140096

GO:1900006

HMNXSV003058035

ILMN_1753135

PH_hs_0024837

TC02001708.hg

U66559_at

g1848243_3p_a_at

Participates

as a component of

ALK G1269S dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-7Y ALK T1087I [plasma membrane]

p-7Y ALK R1061Q [plasma membrane]

p-7Y ALK L1196M [plasma membrane]

p-7Y ALK M1166R [plasma membrane]

p-Y ALK S1206C [plasma membrane]

p- 7Y ALK L1122V [plasma membrane]

p-7Y ALK E1384K [plasma membrane]

p-7Y ALK L1196Q [plasma membrane]

p-7Y ALK V1180L [plasma membrane]

p-7Y ALK G1201R [plasma membrane]

p-7Y ALK I1171T [plasma membrane]

p-7Y ALK R1275L [plasma membrane]

p-7Y ALK F1174C [plasma membrane]

p-7Y ALK F1174V [plasma membrane]

p-7Y ALK M1166N [plasma membrane]

p-7Y ALK M1166T [plasma membrane]

p-7Y ALK Y1239H [plasma membrane]

p-7Y ALK R1275* [plasma membrane]

p-7Y ALK I1171S [plasma membrane]

p-7Y ALK G1128S [plasma membrane]

p-7Y ALK G1128V [plasma membrane]

p-7Y ALK H694R [plasma membrane]

p-7Y ALK G881D [plasma membrane]

p-7Y ALK V597A [plasma membrane]

p-7Y ALK S413N [plasma membrane]

ALK H694R [plasma membrane]

ALK del318-782 [plasma membrane]

ALK H224_G318del [plasma membrane]

ALK V597A [plasma membrane]

ALK S413N [plasma membrane]

ALK G881D [plasma membrane]

ALK T1087I [plasma membrane]

ALK K1062M [plasma membrane]

ALK R1061Q [plasma membrane]

ALK G1201E [plasma membrane]

ALK M1166R [plasma membrane]

ALK E1384K [plasma membrane]

ALK R1275* [plasma membrane]

ALK G1201R [plasma membrane]

ALK R1275L [plasma membrane]

ALK M1166N [plasma membrane]

ALK M1166T [plasma membrane]

ALK G1128V [plasma membrane]

ALK G1128S [plasma membrane]

ALK Y1239H [plasma membrane]

ALK F1174S [plasma membrane]

p-7Y ALK del224-318 [plasma membrane]

p-7Y ALK R1275Q [plasma membrane]

p-7Y ALK G1201E [plasma membrane]

p-7Y ALK K1062M [plasma membrane]

p-7Y ALK del318-782 [plasma membrane]

p-7Y ALK L1198F [plasma membrane]

p-7Y ALK R1192P [plasma membrane]

p-7Y ALK F1245C [plasma membrane]

p-7Y ALK G1128A [plasma membrane]

p-7Y ALK F1174S [plasma membrane]

p-7Y ALK I1171N [plasma membrane]

p-7Y ALK F1174L [plasma membrane]

p-7Y ALK F1174I [plasma membrane]

ALK G1128A [plasma membrane]

ALK S1206F [plasma membrane]

ALK T1151dup [plasma membrane]

ALK C1156Y [plasma membrane]

ALK R1192P [plasma membrane]

ALK T1151M [plasma membrane]

ALK L1122V [plasma membrane]

ALK L1152R [plasma membrane]

ALK A1234T [plasma membrane]

ALK D1203N [plasma membrane]

ALK L1198P [plasma membrane]

ALK G1202R [plasma membrane]

ALK I1171S [plasma membrane]

ALK S1206C [plasma membrane]

ALK F1174C [plasma membrane]

ALK I1171N [plasma membrane]

p-7Y-ALK [plasma membrane]

ALK [plasma membrane]

ALK L1196Q [plasma membrane]

ALK L1196M [plasma membrane]

ALK F1174L [plasma membrane]

ALK R1275Q [plasma membrane]

ALK L1198F [plasma membrane]

ALK S1206Y [plasma membrane]

ALK F1174I [plasma membrane]

ALK V1180L [plasma membrane]

ALK I1171T [plasma membrane]

ALK F1174V [plasma membrane]

ALK G1269A [plasma membrane]

Modified Residues

Name

glycine 1269 replaced with L-serine

Coordinate

1269

PsiMod

glycine removal [MOD:01638]

A protein modification that effectively removes or replaces an glycine.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Cross References

RefSeq

NP_004295.2

ZINC - World Drugs

ALK_HUMAN

Guide to Pharmacology - Targets

1839

OpenTargets

ENSG00000171094

ZINC - FDA approved

ALK_HUMAN

ZINC - Substances

ALK_HUMAN

ZINC - Biogenic

ALK_HUMAN

ZINC target

Q9UM73

PRO

Q9UM73

PDB

4CTB, 7LRZ, 5IMX, 7JYS, 4ANS, 5IUI, 7R7R, 7JYR, 2KUQ, 2YJR, 7LS0, 4CLJ, 4TT7, 5VZ5, 6MX8, 4CMT, 5FTO, 4FNZ, 4CTC, 2YJS, 4Z55, 2KUP, 7NX4, 4CD0, 3LCS, 4ANL, 2YS5, 5AA9, 5IUH, 5AAB, 4JOA, 6EBW, 3LCT, 4CCB, 4CMU, 6E0R, 4CMO, 2YFX, 5A9U, 2XBA, 4CLI, 6AT9, 5KZ0, 2YHV, 7MZW, 7NX3, 7NWZ, 4FNX, 2XP2, 4FNY, 4CNH, 2YT2, 4DCE, 4CCU, 5FTQ, 2XB7, 3L9P, 4FOC, 8ARJ, 7MZY, 7JYT, 7BTT, 4FOB, 6CDT, 5AA8, 7N00, 7JY4, 5IUG, 5AAA, 4FOD, 3AOX, 4MKC, 7R7K, 5AAC, 4ANQ, 4FNW, 6EDL

ZINC - Investigational

ALK_HUMAN

ZINC - Metabolites

ALK_HUMAN

HPA

ENSG00000171094-ALK

GeneCards

Q9UM73

Ensembl

ENSP00000373700, ENSG00000171094, ENST00000389048

Pharos - Targets

Q9UM73

Orphanet

17442

ZINC - Predictions - Purchasable

ALK_HUMAN

HMDB Protein

HMDBP01223

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UXT8 FAM150A	1	ALKAL1 [extracellular region] (R-HSA-9842576)	0.655	7
ChEBI:64310 CRIZOTINIB			0.59	9
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.569	3
ChEBI:62268 CH5424802			0.558	3
UniProt:Q6UX46 FAM150B	2	HC-ALKAL2 [extracellular region] (R-HSA-9842575) ALKAL2 [extracellular region] (R-HSA-9842580)	0.556	5
UniProt:P23471 PTPRZ1	2	PTPRZ1 [plasma membrane] (R-HSA-374561) C4S-PTPRZ1 [plasma membrane] (R-HSA-9699799)	0.544	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.499	2
UniProt:P29317 EPHA2	2	EPHA2 [plasma membrane] (R-HSA-211422) p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380)	0.483	2
UniProt:P29376 LTK	2	p-6Y-LTK [plasma membrane] (R-HSA-9842578) LTK [plasma membrane] (R-HSA-9842564)	0.483	2
UniProt:Q9Y2U8 LEMD3	4	LEMD3 [endosome membrane] (R-HSA-9715091) LEMD3 [endoplasmic reticulum membrane] (R-HSA-9714458) LEMD3 [plasma membrane] (R-HSA-9715186) LEMD3 [nuclear envelope] (R-HSA-2993886)	0.483	2

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