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HC-ALKAL2 [extracellular region]
Stable Identifier
R-HSA-9842575
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FAM150B, fullName evidence="12"ALK and LTK ligand 2, ALKL2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
ALK autophosphorylation (Homo sapiens)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
ALK binds ALKAL ligand (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
ALK-stimulated MYCN gene expression (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK binds FRS2 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK binds JAK3 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK binds PLCG1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK binds SHC1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK binds SRC (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK dimer binds IRS1 (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates FRS2 (Homo sapiens)
Active ALK:FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-6Y FRS2 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates IRS1 (Homo sapiens)
Active ALK:IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:pY-IRS1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates PLCG1 (Homo sapiens)
Active ALK:PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates SHC1 (Homo sapiens)
Active ALK:SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-3Y SHC1 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK phosphorylates SRC (Homo sapiens)
Active ALK:SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-Y419 SRC [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK recruits PI3K (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
ligand-bound ALK dimer [plasma membrane] (Homo sapiens)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
PTPN6 dephosphorylates JAK3 (Homo sapiens)
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
Active ALK:p-Y980 JAK3 [plasma membrane] (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
STAT3 is phosphorylated downstream of active ALK (Homo sapiens)
Active ALK dimer [plasma membrane] (Homo sapiens)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Homo sapiens)
ALKAL2:(ALKAL1) [extracellular region] (Homo sapiens)
ALKAL2 dimer [extracellular region] (Homo sapiens)
HC-ALKAL2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6UX46 FAM150B
Gene Names
FAM150B, UNQ542/PRO1097, ALKAL2
Chain
signal peptide:1-24, chain:25-152
Reference Genes
BioGPS Gene:285016 FAM150B
COSMIC (genes):ALKAL2 FAM150B
CTD Gene:285016 FAM150B
dbSNP Gene:285016 FAM150B
ENSEMBL:ENSG00000189292 FAM150B
HGNC:27683 FAM150B
Monarch:285016 FAM150B
NCBI Gene:285016 FAM150B
OMIM:619671 FAM150B
UCSC:Q6UX46 FAM150B
Reference Transcript
RefSeq:NM_001002919.2 FAM150B
RefSeq:XM_005264689.4 FAM150B
Other Identifiers
11729445_at
16893748
238018_PM_at
238018_at
2537172
2537175
2537176
2537180
2537181
2537182
2537183
2537184
2537185
2537186
2537187
2537188
2537191
2537196
285016
77135_at
8049990
87161_s_at
87162_r_at
A_24_P561341
A_33_P3320197
GE810975
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0007165
GO:0007169
GO:0010976
GO:0030297
GO:0030298
GO:0030971
GO:0048018
GO:0070374
GO:0070378
GO:0098772
HMNXSV003029522
HMNXSV003034364
Hs.213923.0.A1_3p_at
ILMN_2089752
TC02001496.hg
Participates
as a component of
ALKAL2 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
ALKAL2 [extracellular region]
Inferred To
ALKAL2 [extracellular region]
(Bos taurus)
ALKAL2 [extracellular region]
(Canis familiaris)
ALKAL2 [extracellular region]
(Sus scrofa)
Alkal2 [extracellular region]
(Mus musculus)
Alkal2 [extracellular region]
(Rattus norvegicus)
alkal2b [extracellular region]
(Danio rerio)
FAM150B [extracellular region]
(Gallus gallus)
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 66 and 66
Coordinate
66
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
ENSEMBL
ENST00000403610
,
ENSP00000384604
OpenTargets
ENSG00000189292
HPA
ENSG00000189292-ALKAL2
PRO
Q6UX46
Pharos - Targets
Q6UX46
PDB
7LS0
,
7N00
,
7NWZ
,
7MZX
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UM73 ALK
20
p-7Y ALK T1087I [plasma membrane]
(R-HSA-9723885)
p-7Y ALK R1061Q [plasma membrane]
(R-HSA-9723884)
p-7Y ALK L1196M [plasma membrane]
(R-HSA-9700464)
p-7Y ALK M1166R [plasma membrane]
(R-HSA-9700477)
p-Y ALK S1206C [plasma membrane]
(R-HSA-9715292)
p- 7Y ALK L1122V [plasma membrane]
(R-HSA-9715294)
p-7Y ALK E1384K [plasma membrane]
(R-HSA-9715285)
p-7Y ALK L1196Q [plasma membrane]
(R-HSA-9700476)
p-7Y ALK V1180L [plasma membrane]
(R-HSA-9715289)
p-7Y ALK G1201R [plasma membrane]
(R-HSA-9701860)
p-7Y ALK I1171T [plasma membrane]
(R-HSA-9700489)
p-7Y ALK R1275L [plasma membrane]
(R-HSA-9699800)
p-7Y ALK F1174C [plasma membrane]
(R-HSA-9699821)
p-7Y ALK F1174V [plasma membrane]
(R-HSA-9699921)
p-7Y ALK M1166N [plasma membrane]
(R-HSA-9723299)
p-7Y ALK M1166T [plasma membrane]
(R-HSA-9700486)
p-7Y ALK Y1239H [plasma membrane]
(R-HSA-9715290)
p-7Y ALK R1275* [plasma membrane]
(R-HSA-9699915)
p-7Y ALK I1171S [plasma membrane]
(R-HSA-9714063)
p-7Y ALK G1128S [plasma membrane]
(R-HSA-9700462)
0.556
5
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